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10.1089/aid.2013.0009

http://scihub22266oqcxt.onion/10.1089/aid.2013.0009
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C3653373!3653373!23495713
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suck abstract from ncbi


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pmid23495713      AIDS+Res+Hum+Retroviruses 2013 ; 29 (6): 963-70
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  • Dynamics of HIV Type 1 Recombination Following Superinfection #MMPMID23495713
  • Koning FA; Badhan A; Shaw S; Fisher M; Mbisa JL; Cane PA
  • AIDS Res Hum Retroviruses 2013[Jun]; 29 (6): 963-70 PMID23495713show ga
  • There are currently few detailed studies describing HIV-1 recombination events or the potential impact of recombination on drug resistance. We describe here the viral recombination dynamics in a drug-naive patient initially infected with a circulating recombinant form 19 (CRF19) virus containing transmitted drug resistance mutations followed by superinfection with ?wild-type? subtype B virus. Single genome analysis showed replacement of the primary CRF19 virus by recombinants of the CRF19 virus and the superinfecting subtype B virus. The CRF19/B recombinant virus dominating after superinfection had lost drug resistance mutations and at no time was the superinfecting subtype B variant found to be dominant in blood plasma. Furthermore, the detection of recombinant viruses in seminal plasma indicates the potential for onward transmission of these strains.
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