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Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Immunology 2013 ; 139 (2): 161-5 Nephropedia Template TP
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The MYSTerious MOZ, a histone acetyltransferase with a key role in haematopoiesis #MMPMID23347099
Perez-Campo FM; Costa G; Lie-a-Ling M; Kouskoff V; Lacaud G
Immunology 2013[Jun]; 139 (2): 161-5 PMID23347099show ga
The MOnocytic leukaemia Zing finger (MOZ; MYST3 or KAT6A1) gene is frequently found translocated in acute myeloid leukaemia. MOZ encodes a large multidomain protein that contains, besides others, a histone acetyl transferase catalytic domain. Several studies have now established the critical function of MOZ in haematopoiesis. In this review we summarize the recent findings that underscore the relevance of the different biological activities of MOZ in the regulation of haematopoiesis.