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10.1089/ars.2012.4834 http://scihub22266oqcxt.onion/10.1089/ars.2012.4834 C3638564!3638564!22900885     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Antioxid+Redox+Signal 2013 ; 18 (17): 2352-63 Nephropedia Template TP {{tp|p=22900885|t=2013. CD163 and Inflammation: Biological, Diagnostic, and Therapeutic Aspects |pdf=|usr=}}{{22900885}} gab.com Text CD163 and Inflammation: Biological, Diagnostic, and Therapeutic Aspects JO: Antioxid Redox Signal http://www.kidney.de/pget.php?&tw=1&pmid=22900885 #FOAvip Significance: The hemoglobin (Hb) scavenger receptor, CD163, is a macrophage-specific protein and the upregulated expression of this receptor is one of the major changes in the macrophage switch to alternative activated phenotypes in inflammation. Accordingly, a high CD163 expression in macrophages is a characteristic of tissues responding to inflammation. The scavenging of the oxidative and proinflammatory Hb leading to stimulation of the heme-oxygenase-1 and production of anti-inflammatory heme metabolites indicates that CD163 thereby indirectly contributes to the anti-inflammatory response. Recent Advances: In addition to this biological role in inflammation, CD163 is a potential inflammation biomarker and a therapeutic target. The biomarker form of CD163 is the soluble plasma CD163 that arises from the increased shedding of CD163 mediated by the tumor necrosis factor-? (TNF-?) cleaving enzyme. This explains that a steadily increasing literature documents that the plasma level of soluble CD163 is increased in a large spectrum of acute and chronic inflammatory disorders. The nonshed membrane form of CD163 in macrophages constitutes a target for drugs to be directed to macrophages in inflammation. This approach has been used in an animal inflammation model to highly increase the apparent therapeutic index of anti-inflammatory glucocorticoid drug that was coupled to an anti-CD163 antibody. Furthermore, other recent animal data, which indirectly involve CD163 in macrophages, demonstrate that injections of haptoglobin attenuate Hb-induced damages after blood transfusion. Critical Issues and Future Directions: The diagnostic and therapeutic properties of CD163 await further clinical studies and regulatory approval before implementation in the clinic. Antioxid. Redox Signal. 18, 2352?2363. Twit Text FOAVip CD163 and Inflammation: Biological, Diagnostic, and Therapeutic Aspects ????Antioxid Redox Signal http://www.kidney.de/pget.php?&tw=1&pmid=22900885 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=22900885 #FOAvip English Wikipedia <ref>{{Cite pmid|22900885}}</ref> CD163 and Inflammation: Biological, Diagnostic, and Therapeutic Aspects #MMPMID22900885 Etzerodt A; Moestrup SK Antioxid Redox Signal 2013[Jun]; 18 (17): 2352-63 PMID22900885show ga Significance: The hemoglobin (Hb) scavenger receptor, CD163, is a macrophage-specific protein and the upregulated expression of this receptor is one of the major changes in the macrophage switch to alternative activated phenotypes in inflammation. Accordingly, a high CD163 expression in macrophages is a characteristic of tissues responding to inflammation. The scavenging of the oxidative and proinflammatory Hb leading to stimulation of the heme-oxygenase-1 and production of anti-inflammatory heme metabolites indicates that CD163 thereby indirectly contributes to the anti-inflammatory response. Recent Advances: In addition to this biological role in inflammation, CD163 is a potential inflammation biomarker and a therapeutic target. The biomarker form of CD163 is the soluble plasma CD163 that arises from the increased shedding of CD163 mediated by the tumor necrosis factor-? (TNF-?) cleaving enzyme. This explains that a steadily increasing literature documents that the plasma level of soluble CD163 is increased in a large spectrum of acute and chronic inflammatory disorders. The nonshed membrane form of CD163 in macrophages constitutes a target for drugs to be directed to macrophages in inflammation. This approach has been used in an animal inflammation model to highly increase the apparent therapeutic index of anti-inflammatory glucocorticoid drug that was coupled to an anti-CD163 antibody. Furthermore, other recent animal data, which indirectly involve CD163 in macrophages, demonstrate that injections of haptoglobin attenuate Hb-induced damages after blood transfusion. Critical Issues and Future Directions: The diagnostic and therapeutic properties of CD163 await further clinical studies and regulatory approval before implementation in the clinic. Antioxid. Redox Signal. 18, 2352?2363. äCD163 and Inflammation: Biological, Diagnostic, and Therapeutic Aspect(epmc).pdf DeepDyve Pubget Overpricing