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10.1007/s11357-012-9388-8 http://scihub22266oqcxt.onion/10.1007/s11357-012-9388-8 C3636394!3636394!22382760     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Age+(Dordr) 2013 ; 35 (3): 583-96 Nephropedia Template TP {{tp|p=22382760|t=2013. Accumulated hippocampal formaldehyde induces age-dependent memory decline |pdf=|usr=}}{{22382760}} gab.com Text Accumulated hippocampal formaldehyde induces age-dependent memory decline JO: Age (Dordr) http://www.kidney.de/pget.php?&tw=1&pmid=22382760 #FOAvip Aging is an important factor in memory decline in aged animals and humans and in Alzheimer?s disease and is associated with the impairment of hippocampal long-term potentiation (LTP) and down-regulation of NR1/NR2B expression. Gaseous formaldehyde exposure is known to induce animal memory loss and human cognitive decline; however, it is unclear whether the concentrations of endogenous formaldehyde are elevated in the hippocampus and how excess formaldehyde affects LTP and memory formation during the aging process. In the present study, we report that hippocampal formaldehyde accumulated in memory-deteriorating diseases such as age-related dementia. Spatial memory performance was gradually impaired in normal Sprague?Dawley rats by persistent intraperitoneal injection with formaldehyde. Furthermore, excess formaldehyde treatment suppressed the hippocampal LTP formation by blocking N-methyl-d-aspartate (NMDA) receptor. Chronic excess formaldehyde treatment over a period of 30 days markedly decreased the viability of the hippocampus and down-regulated the expression of the NR1 and NR2B subunits of the NMDA receptor. Our results indicate that excess endogenous formaldehyde is a critical factor in memory loss in age-related memory-deteriorating diseases. Twit Text FOAVip Accumulated hippocampal formaldehyde induces age-dependent memory decline ????Age (Dordr) http://www.kidney.de/pget.php?&tw=1&pmid=22382760 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=22382760 #FOAvip English Wikipedia <ref>{{Cite pmid|22382760}}</ref> Accumulated hippocampal formaldehyde induces age-dependent memory decline #MMPMID22382760 Tong Z; Han C; Luo W; Wang X; Li H; Luo H; Zhou J; Qi J; He R Age (Dordr) 2013[Jun]; 35 (3): 583-96 PMID22382760show ga Aging is an important factor in memory decline in aged animals and humans and in Alzheimer?s disease and is associated with the impairment of hippocampal long-term potentiation (LTP) and down-regulation of NR1/NR2B expression. Gaseous formaldehyde exposure is known to induce animal memory loss and human cognitive decline; however, it is unclear whether the concentrations of endogenous formaldehyde are elevated in the hippocampus and how excess formaldehyde affects LTP and memory formation during the aging process. In the present study, we report that hippocampal formaldehyde accumulated in memory-deteriorating diseases such as age-related dementia. Spatial memory performance was gradually impaired in normal Sprague?Dawley rats by persistent intraperitoneal injection with formaldehyde. Furthermore, excess formaldehyde treatment suppressed the hippocampal LTP formation by blocking N-methyl-d-aspartate (NMDA) receptor. Chronic excess formaldehyde treatment over a period of 30 days markedly decreased the viability of the hippocampus and down-regulated the expression of the NR1 and NR2B subunits of the NMDA receptor. Our results indicate that excess endogenous formaldehyde is a critical factor in memory loss in age-related memory-deteriorating diseases. äAccumulated hippocampal formaldehyde induces age-dependent memory decl(epmc).pdf DeepDyve Pubget Overpricing