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10.4049/jimmunol.1202096 http://scihub22266oqcxt.onion/10.4049/jimmunol.1202096 C3633673!3633673 !23526820     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=23526820 &cmd=llinks): Failed to open stream: HTTP request failed! 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Inflammatory response of mast cells during influenza A virus infection is mediated by active infection and RIG-I signaling |pdf=|usr=}}{{23526820 }} gab.com Text Inflammatory response of mast cells during influenza A virus infection is mediated by active infection and RIG-I signaling JO: J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=23526820 #FOAvip Influenza A virus (IAV) is a major respiratory pathogen of both humans and animals. The lung is protected from pathogens by alveolar epithelial cells, tissue-resident alveolar macrophages, dendritic cells, and mast cells. The role of alveolar epithelial cells, endothelial cells, and alveolar macrophages during IAV infection has been studied previously. In this study, we address the role of mast cells during IAV infection. Respiratory infection with A/WSN/33 causes significant disease and immunopathology in C57BL/6 mice but not in B6.Cg-Kit(W-sh) mice, which lack mast cells. During in vitro coculture, A/WSN/33 caused mast cells to release histamine, secrete cytokines and chemokines, and produce leukotrienes. Moreover, when mast cells were infected with IAV, the virus did not replicate within mast cells. Importantly, human H1N1, H3N2, and influenza B virus isolates also could activate mast cells in vitro. Mast cell production of cytokines and chemokines occurs in a RIG-I/MAVS-dependent mechanism; in contrast, histamine production occurred through a RIG-I/MAVS-independent mechanism. Our data highlight that, following IAV infection, the response of mast cells is controlled by multiple receptors. In conclusion, we identified a unique inflammatory cascade activated during IAV infection that could potentially be targeted to limit morbidity following IAV infection. Twit Text FOAVip Inflammatory response of mast cells during influenza A virus infection is mediated by active infection and RIG-I signaling ????J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=23526820 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=23526820 #FOAvip English Wikipedia <ref>{{Cite pmid|23526820 }}</ref> Inflammatory response of mast cells during influenza A virus infection is mediated by active infection and RIG-I signaling #MMPMID23526820 Graham AC ; Hilmer KM ; Zickovich JM ; Obar JJ J Immunol 2013[May]; 190 (9 ): 4676-84 PMID23526820 show ga Influenza A virus (IAV) is a major respiratory pathogen of both humans and animals. The lung is protected from pathogens by alveolar epithelial cells, tissue-resident alveolar macrophages, dendritic cells, and mast cells. The role of alveolar epithelial cells, endothelial cells, and alveolar macrophages during IAV infection has been studied previously. In this study, we address the role of mast cells during IAV infection. Respiratory infection with A/WSN/33 causes significant disease and immunopathology in C57BL/6 mice but not in B6.Cg-Kit(W-sh) mice, which lack mast cells. During in vitro coculture, A/WSN/33 caused mast cells to release histamine, secrete cytokines and chemokines, and produce leukotrienes. Moreover, when mast cells were infected with IAV, the virus did not replicate within mast cells. Importantly, human H1N1, H3N2, and influenza B virus isolates also could activate mast cells in vitro. Mast cell production of cytokines and chemokines occurs in a RIG-I/MAVS-dependent mechanism; in contrast, histamine production occurred through a RIG-I/MAVS-independent mechanism. Our data highlight that, following IAV infection, the response of mast cells is controlled by multiple receptors. In conclusion, we identified a unique inflammatory cascade activated during IAV infection that could potentially be targeted to limit morbidity following IAV infection. |Animals [MESH] |Chemokines/immunology/metabolism [MESH] |DEAD-box RNA Helicases/immunology/*metabolism [MESH] |Histamine/immunology/metabolism [MESH] |Humans [MESH] |Inflammation/*immunology/metabolism/virology [MESH] |Influenza A Virus, H1N1 Subtype/immunology [MESH] |Influenza A Virus, H3N2 Subtype/immunology [MESH] |Influenza, Human/*immunology/metabolism/virology [MESH] |Leukotrienes/immunology/metabolism [MESH] |Lung/immunology/metabolism/virology [MESH] |Mast Cells/*immunology/metabolism/virology [MESH] |Membrane Proteins/immunology/metabolism [MESH] |Mice [MESH] |Mice, Inbred C57BL [MESH] |Orthomyxoviridae Infections/*immunology/metabolism/virology [MESH]Inflammatory response of mast cells during influenza A virus infection(epmc).pdf DeepDyve Pubget Overpricing