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10.1016/j.bbagrm.2012.12.003

http://scihub22266oqcxt.onion/10.1016/j.bbagrm.2012.12.003
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C3632658!3632658!23274304
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suck abstract from ncbi


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pmid23274304      Biochim+Biophys+Acta+Gene+Regul+Mech 2013 ; 1829 (6): 732-41
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  • Interplay between viruses and host mRNA degradation? #MMPMID23274304
  • Narayanan K; Makino S
  • Biochim Biophys Acta Gene Regul Mech 2013[Jun]; 1829 (6): 732-41 PMID23274304show ga
  • Messenger RNA degradation is a fundamental cellular process that plays a critical role in regulating gene expression by controlling both the quality and the abundance of mRNAs in cells. Naturally, viruses must successfully interface with the robust cellular RNA degradation machinery to achieve an optimal balance between viral and cellular gene expression and establish a productive infection in the host. In the past several years, studies have discovered many elegant strategies that viruses have evolved to circumvent the cellular RNA degradation machinery, ranging from disarming the RNA decay pathways and co-opting the factors governing cellular mRNA stability to promoting host mRNA degradation that facilitates selective viral gene expression and alters the dynamics of host?pathogen interaction. This review summarizes the current knowledge of the multifaceted interaction between viruses and cellular mRNA degradation machinery to provide an insight into the regulatory mechanisms that influence gene expression in viral infections. This article is part of a Special Issue entitled: RNA Decay mechanisms.
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