Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1371/journal.ppat.1003256 http://scihub22266oqcxt.onion/10.1371/journal.ppat.1003256 C3623797!3623797 !23592984     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\23592984 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       PLoS+Pathog 2013 ; 9 (4 ): e1003256 Nephropedia Template TP {{tp|p=23592984 |t=2013. Type I IFN triggers RIG-I/TLR3/NLRP3-dependent inflammasome activation in influenza A virus infected cells |pdf=|usr=}}{{23592984 }} gab.com Text Type I IFN triggers RIG-I/TLR3/NLRP3-dependent inflammasome activation in influenza A virus infected cells JO: PLoS Pathog http://www.kidney.de/pget.php?&tw=1&pmid=23592984 #FOAvip Influenza A virus (IAV) triggers a contagious and potentially lethal respiratory disease. A protective IL-1? response is mediated by innate receptors in macrophages and lung epithelial cells. NLRP3 is crucial in macrophages; however, which sensors elicit IL-1? secretion in lung epithelial cells remains undetermined. Here, we describe for the first time the relative roles of the host innate receptors RIG-I (DDX58), TLR3, and NLRP3 in the IL-1? response to IAV in primary lung epithelial cells. To activate IL-1? secretion, these cells employ partially redundant recognition mechanisms that differ from those described in macrophages. RIG-I had the strongest effect through a MAVS/TRIM25/Riplet-dependent type I IFN signaling pathway upstream of TLR3 and NLRP3. Notably, RIG-I also activated the inflammasome through interaction with caspase 1 and ASC in primary lung epithelial cells. Thus, NS1, an influenza virulence factor that inhibits the RIG-I/type I IFN pathway, strongly modulated the IL-1? response in lung epithelial cells and in ferrets. The NS1 protein derived from a highly pathogenic strain resulted in increased interaction with RIG-I and inhibited type I IFN and IL-1? responses compared to the least pathogenic virus strains. These findings demonstrate that in IAV-infected lung epithelial cells RIG-I activates the inflammasome both directly and through a type I IFN positive feedback loop. Twit Text FOAVip Type I IFN triggers RIG-I/TLR3/NLRP3-dependent inflammasome activation in influenza A virus infected cells ????PLoS Pathog http://www.kidney.de/pget.php?&tw=1&pmid=23592984 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=23592984 #FOAvip English Wikipedia <ref>{{Cite pmid|23592984 }}</ref> Type I IFN triggers RIG-I/TLR3/NLRP3-dependent inflammasome activation in influenza A virus infected cells #MMPMID23592984 Pothlichet J ; Meunier I ; Davis BK ; Ting JP ; Skamene E ; von Messling V ; Vidal SM PLoS Pathog 2013[]; 9 (4 ): e1003256 PMID23592984 show ga Influenza A virus (IAV) triggers a contagious and potentially lethal respiratory disease. A protective IL-1? response is mediated by innate receptors in macrophages and lung epithelial cells. NLRP3 is crucial in macrophages; however, which sensors elicit IL-1? secretion in lung epithelial cells remains undetermined. Here, we describe for the first time the relative roles of the host innate receptors RIG-I (DDX58), TLR3, and NLRP3 in the IL-1? response to IAV in primary lung epithelial cells. To activate IL-1? secretion, these cells employ partially redundant recognition mechanisms that differ from those described in macrophages. RIG-I had the strongest effect through a MAVS/TRIM25/Riplet-dependent type I IFN signaling pathway upstream of TLR3 and NLRP3. Notably, RIG-I also activated the inflammasome through interaction with caspase 1 and ASC in primary lung epithelial cells. Thus, NS1, an influenza virulence factor that inhibits the RIG-I/type I IFN pathway, strongly modulated the IL-1? response in lung epithelial cells and in ferrets. The NS1 protein derived from a highly pathogenic strain resulted in increased interaction with RIG-I and inhibited type I IFN and IL-1? responses compared to the least pathogenic virus strains. These findings demonstrate that in IAV-infected lung epithelial cells RIG-I activates the inflammasome both directly and through a type I IFN positive feedback loop. |*Influenza A Virus, H1N1 Subtype/metabolism [MESH] |Adaptor Proteins, Signal Transducing/metabolism [MESH] |Animals [MESH] |CARD Signaling Adaptor Proteins [MESH] |Carrier Proteins/genetics/*metabolism [MESH] |Caspase 1/genetics/metabolism [MESH] |Cells, Cultured [MESH] |Cytoskeletal Proteins/metabolism [MESH] |DEAD Box Protein 58 [MESH] |DEAD-box RNA Helicases/genetics/*metabolism [MESH] |Epithelial Cells/metabolism [MESH] |Ferrets [MESH] |HEK293 Cells [MESH] |Humans [MESH] |Inflammasomes/*metabolism [MESH] |Interferon-beta/*metabolism [MESH] |Lung/metabolism/virology [MESH] |Macrophages/immunology [MESH] |Male [MESH] |NLR Family, Pyrin Domain-Containing 3 Protein [MESH] |RNA Interference [MESH] |Receptors, Immunologic [MESH] |Respiratory Mucosa/cytology/immunology [MESH] |Signal Transduction [MESH] |Toll-Like Receptor 3/genetics/*metabolism [MESH] |Transcription Factors/metabolism [MESH] |Tripartite Motif Proteins [MESH] |Ubiquitin-Protein Ligases/metabolism [MESH]Type I IFN triggers RIG-I/TLR3/NLRP3-dependent inflammasome activation(epmc).pdf DeepDyve Pubget Overpricing