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2012 ; 20
(1
): 74
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The efficacy of magnesium sulfate loading on microalbuminuria following SIRS: One
step forward in dosing
#MMPMID23351890
Mirrahimi B
; Hamishehkar H
; Ahmadi A
; Mirjalili MR
; Aghamohamadi M
; Najafi A
; Abdollahi M
; Mojtahedzahed M
Daru
2012[Oct]; 20
(1
): 74
PMID23351890
show ga
BACKGROUNDS: Magnesium has been known for its antioxidative and antiinflammatory
properties in many studies. In this study two dosing regimens of magnesium were
compared with a placebo control group in order to investigate safety and efficacy
of high doses of intravenous magnesium sulfate infusion on critically ill trauma
patients. Inflammatory and oxidative factors were measured in this trial.
METHODS: 45 trauma patients with systemic inflammatory response syndromes (SIRS)
were randomly assigned into 2 treatment and one placebo groups. The high dose
group received 15?g MgSO4, low dose group received 7.5?g of MgSO4 over 4?hour
infusion, and placebo group received saline alone. The initial and post magnesium
sulfate injections levels of tumor necrosis factor alpha (TNF-?), total
antioxidant power and lipid peroxidation were measured after 6, 18 and 36?hours.
The pre-infusion along with 6 and 36?hour level of microalbuminuria were also
determined. RESULTS: Repeated measurements illustrated that there was no
significant difference in TNF-?, total antioxidant power and lipid peroxidation
levels among groups during the period of analysis. The microalbuminuria at
36?hour post infusion of high dose group was lower than that of control group
(p?=?0.024). Patient's mortality (28?day) was similar among all treatment groups.
Both magnesium infusion groups tolerated the drug without experiencing any
complications. CONCLUSION: No evidence for antioxidative and antiinflammatory
effects of magnesium in traumatic SIRS positive patients was found. Magnesium in
high doses may be recommended for traumatic patients with SIRS status to prevent
microalbuminuria.