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10.1186/2008-2231-20-74 http://scihub22266oqcxt.onion/10.1186/2008-2231-20-74 C3556002!3556002 !23351890     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=23351890 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       Daru 2012 ; 20 (1 ): 74 Nephropedia Template TP {{tp|p=23351890 |t=2012. The efficacy of magnesium sulfate loading on microalbuminuria following SIRS: One step forward in dosing |pdf=|usr=}}{{23351890 }} gab.com Text The efficacy of magnesium sulfate loading on microalbuminuria following SIRS: One step forward in dosing JO: Daru http://www.kidney.de/pget.php?&tw=1&pmid=23351890 #FOAvip BACKGROUNDS: Magnesium has been known for its antioxidative and antiinflammatory properties in many studies. In this study two dosing regimens of magnesium were compared with a placebo control group in order to investigate safety and efficacy of high doses of intravenous magnesium sulfate infusion on critically ill trauma patients. Inflammatory and oxidative factors were measured in this trial. METHODS: 45 trauma patients with systemic inflammatory response syndromes (SIRS) were randomly assigned into 2 treatment and one placebo groups. The high dose group received 15?g MgSO4, low dose group received 7.5?g of MgSO4 over 4?hour infusion, and placebo group received saline alone. The initial and post magnesium sulfate injections levels of tumor necrosis factor alpha (TNF-?), total antioxidant power and lipid peroxidation were measured after 6, 18 and 36?hours. The pre-infusion along with 6 and 36?hour level of microalbuminuria were also determined. RESULTS: Repeated measurements illustrated that there was no significant difference in TNF-?, total antioxidant power and lipid peroxidation levels among groups during the period of analysis. The microalbuminuria at 36?hour post infusion of high dose group was lower than that of control group (p?=?0.024). Patient's mortality (28?day) was similar among all treatment groups. Both magnesium infusion groups tolerated the drug without experiencing any complications. CONCLUSION: No evidence for antioxidative and antiinflammatory effects of magnesium in traumatic SIRS positive patients was found. Magnesium in high doses may be recommended for traumatic patients with SIRS status to prevent microalbuminuria. Twit Text FOAVip The efficacy of magnesium sulfate loading on microalbuminuria following SIRS: One step forward in dosing ????Daru http://www.kidney.de/pget.php?&tw=1&pmid=23351890 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=23351890 #FOAvip English Wikipedia <ref>{{Cite pmid|23351890 }}</ref> The efficacy of magnesium sulfate loading on microalbuminuria following SIRS: One step forward in dosing #MMPMID23351890 Mirrahimi B ; Hamishehkar H ; Ahmadi A ; Mirjalili MR ; Aghamohamadi M ; Najafi A ; Abdollahi M ; Mojtahedzahed M Daru 2012[Oct]; 20 (1 ): 74 PMID23351890 show ga BACKGROUNDS: Magnesium has been known for its antioxidative and antiinflammatory properties in many studies. In this study two dosing regimens of magnesium were compared with a placebo control group in order to investigate safety and efficacy of high doses of intravenous magnesium sulfate infusion on critically ill trauma patients. Inflammatory and oxidative factors were measured in this trial. METHODS: 45 trauma patients with systemic inflammatory response syndromes (SIRS) were randomly assigned into 2 treatment and one placebo groups. The high dose group received 15?g MgSO4, low dose group received 7.5?g of MgSO4 over 4?hour infusion, and placebo group received saline alone. The initial and post magnesium sulfate injections levels of tumor necrosis factor alpha (TNF-?), total antioxidant power and lipid peroxidation were measured after 6, 18 and 36?hours. The pre-infusion along with 6 and 36?hour level of microalbuminuria were also determined. RESULTS: Repeated measurements illustrated that there was no significant difference in TNF-?, total antioxidant power and lipid peroxidation levels among groups during the period of analysis. The microalbuminuria at 36?hour post infusion of high dose group was lower than that of control group (p?=?0.024). Patient's mortality (28?day) was similar among all treatment groups. Both magnesium infusion groups tolerated the drug without experiencing any complications. CONCLUSION: No evidence for antioxidative and antiinflammatory effects of magnesium in traumatic SIRS positive patients was found. Magnesium in high doses may be recommended for traumatic patients with SIRS status to prevent microalbuminuria. ?The efficacy of magnesium sulfate loading on microalbuminuria followin(epmc).pdf DeepDyve Pubget Overpricing