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10.1093/toxsci/kfs315 http://scihub22266oqcxt.onion/10.1093/toxsci/kfs315 C3551428!3551428!23152191     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 278.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 278.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 278.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 278.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Toxicol+Sci 2013 ; 131 (2): 419-33 Nephropedia Template TP {{tp|p=23152191|t=2013. ?9-Tetrahydrocannabinol Impairs the Inflammatory Response to Influenza Infection: Role of Antigen-Presenting Cells and the Cannabinoid Receptors 1 and 2 |pdf=|usr=}}{{23152191}} gab.com Text 9-Tetrahydrocannabinol Impairs the Inflammatory Response to Influenza Infection: Role of Antigen-Presenting Cells and the Cannabinoid Receptors 1 and 2 JO: Toxicol Sci http://www.kidney.de/pget.php?&tw=1&pmid=23152191 #FOAvip ?9-tetrahydrocannabinol (?9-THC) has potent immune modulatory properties and can impair pathogen-induced immune defenses, which in part have been attributed to ligation of the cannabinoid receptors 1 (CB1) and 2 (CB2). Most recently, dendritic cells (DC) were identified for their potential to enhance influenza-induced immunopathology in mice lacking CB1 and CB2 (CB1?/?CB2?/?). This study focused on the modulation of the inflammatory immune response to influenza by ?9-THC and the role of CB1 and/or CB2 as receptor targets for ?9-THC. C57Bl/6 (wild type) and CB1?/?CB2?/? mice were administered ?9-THC (75mg/kg) surrounding the intranasal instillation of A/PR/8/34 influenza virus. Three days post infection (dpi), ?9-THC broadly decreased expression levels of mRNA induced by the innate immune response to influenza, suppressed the percentage of interferon-gamma (IFN-?)?producing CD4+ and interleukin-17?producing NK1.1+ cells, and reduced the influx of antigen-presenting cells (APC), including inflammatory myeloid cells and monocytes/macrophages, into the lung in a CB1- and/or CB2-dependent manner. ?9-THC had little effect on the expression of CD86, major histocompatibility complex I (MHC I), and MHC II by APC isolated from the lung. In vitro studies demonstrated that lipopolysaccharide (LPS)?induced maturation was suppressed by ?9-THC in bone marrow?derived DC (bmDC). Furthermore, antigen-specific IFN-? production by CD8+ T cells after coculture was reduced by ?9-THC treatment of bmDC in a CB1- and/or CB2-dependent manner. Collectively, these studies suggest that ?9-THC potently suppresses myeloid cell immune function, in a manner involving CB1 and/or CB2, thereby impairing immune responses to influenza infection. Twit Text FOAVip 9-Tetrahydrocannabinol Impairs the Inflammatory Response to Influenza Infection: Role of Antigen-Presenting Cells and the Cannabinoid Receptors 1 and 2 ????Toxicol Sci http://www.kidney.de/pget.php?&tw=1&pmid=23152191 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=23152191 #FOAvip English Wikipedia <ref>{{Cite pmid|23152191}}</ref> ?9-Tetrahydrocannabinol Impairs the Inflammatory Response to Influenza Infection: Role of Antigen-Presenting Cells and the Cannabinoid Receptors 1 and 2 #MMPMID23152191 Karmaus PWF; Chen W; Crawford R; Kaplan BLF; Kaminski NE Toxicol Sci 2013[Feb]; 131 (2): 419-33 PMID23152191show ga ?9-tetrahydrocannabinol (?9-THC) has potent immune modulatory properties and can impair pathogen-induced immune defenses, which in part have been attributed to ligation of the cannabinoid receptors 1 (CB1) and 2 (CB2). Most recently, dendritic cells (DC) were identified for their potential to enhance influenza-induced immunopathology in mice lacking CB1 and CB2 (CB1?/?CB2?/?). This study focused on the modulation of the inflammatory immune response to influenza by ?9-THC and the role of CB1 and/or CB2 as receptor targets for ?9-THC. C57Bl/6 (wild type) and CB1?/?CB2?/? mice were administered ?9-THC (75mg/kg) surrounding the intranasal instillation of A/PR/8/34 influenza virus. Three days post infection (dpi), ?9-THC broadly decreased expression levels of mRNA induced by the innate immune response to influenza, suppressed the percentage of interferon-gamma (IFN-?)?producing CD4+ and interleukin-17?producing NK1.1+ cells, and reduced the influx of antigen-presenting cells (APC), including inflammatory myeloid cells and monocytes/macrophages, into the lung in a CB1- and/or CB2-dependent manner. ?9-THC had little effect on the expression of CD86, major histocompatibility complex I (MHC I), and MHC II by APC isolated from the lung. In vitro studies demonstrated that lipopolysaccharide (LPS)?induced maturation was suppressed by ?9-THC in bone marrow?derived DC (bmDC). Furthermore, antigen-specific IFN-? production by CD8+ T cells after coculture was reduced by ?9-THC treatment of bmDC in a CB1- and/or CB2-dependent manner. Collectively, these studies suggest that ?9-THC potently suppresses myeloid cell immune function, in a manner involving CB1 and/or CB2, thereby impairing immune responses to influenza infection. ä?9-Tetrahydrocannabinol Impairs the Inflammatory Response to Influenza(epmc).pdf DeepDyve Pubget Overpricing