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10.4049/jimmunol.1101855 http://scihub22266oqcxt.onion/10.4049/jimmunol.1101855 C3531993/?report=reader!3531993!23018462     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Immunol 2012 ; 189 (9): 4258-65 Nephropedia Template TP {{tp|p=23018462|t=2012. Depletion of plasmacytoid dendritic cells inhibits tumor growth and prevents bone metastasis of the breast cancer cells |pdf=|usr=}}{{23018462}} gab.com Text Depletion of plasmacytoid dendritic cells inhibits tumor growth and prevents bone metastasis of the breast cancer cells JO: J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=23018462 #FOAvip Elevated levels of plasmacytoid dendritic cells (pDC) have been reported in breast cancer patients, the significance of which remains undefined. Using three different immunocompetent mouse models of BCa bone metastasis, we identified a key role for pDC in facilitating tumor growth through immunosuppression and aggressive osteolysis. Following infiltration of macrophages upon breast cancer dissemination, there was a steady increase of pDC within the bone, which resulted in a sustained Th2 response along with elevated levels of Treg and MDSC. Subsequently, pDC and CD4+ T cells, producing osteolytic cytokines, increased with tumor burden causing severe bone damage. Micro-CT and histology analyses of bone showed destruction of femur and tibia. Therapeutic significance of this finding was confirmed by depletion of pDC, which resulted in decreased tumor burden and bone loss by activating tumor-specific cytolytic CD8+ T cells and decreasing suppressor cell populations. Thus, pDC depletion may offer a novel adjuvant strategy to therapeutically influence breast cancer bone metastasis. Twit Text FOAVip Depletion of plasmacytoid dendritic cells inhibits tumor growth and prevents bone metastasis of the breast cancer cells ????J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=23018462 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=23018462 #FOAvip English Wikipedia <ref>{{Cite pmid|23018462}}</ref> Depletion of plasmacytoid dendritic cells inhibits tumor growth and prevents bone metastasis of the breast cancer cells #MMPMID23018462 Sawant A; Hensel JA; Chanda D; Harris BA; Siegal GP; Maheshwari A; Ponnazhagan S J Immunol 2012[Nov]; 189 (9): 4258-65 PMID23018462show ga Elevated levels of plasmacytoid dendritic cells (pDC) have been reported in breast cancer patients, the significance of which remains undefined. Using three different immunocompetent mouse models of BCa bone metastasis, we identified a key role for pDC in facilitating tumor growth through immunosuppression and aggressive osteolysis. Following infiltration of macrophages upon breast cancer dissemination, there was a steady increase of pDC within the bone, which resulted in a sustained Th2 response along with elevated levels of Treg and MDSC. Subsequently, pDC and CD4+ T cells, producing osteolytic cytokines, increased with tumor burden causing severe bone damage. Micro-CT and histology analyses of bone showed destruction of femur and tibia. Therapeutic significance of this finding was confirmed by depletion of pDC, which resulted in decreased tumor burden and bone loss by activating tumor-specific cytolytic CD8+ T cells and decreasing suppressor cell populations. Thus, pDC depletion may offer a novel adjuvant strategy to therapeutically influence breast cancer bone metastasis. äDepletion of plasmacytoid dendritic cells inhibits tumor growth and pr(epmc).pdf DeepDyve Pubget Overpricing