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10.1172/JCI62139 http://scihub22266oqcxt.onion/10.1172/JCI62139 C3461909!3461909!22996662     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Clin+Invest 2012 ; 122 (10): 3652-64 Nephropedia Template TP {{tp|p=22996662|t=2012. Alveolar epithelial cells orchestrate DC function in murine viral pneumonia |pdf=|usr=}}{{22996662}} gab.com Text Alveolar epithelial cells orchestrate DC function in murine viral pneumonia JO: J Clin Invest http://www.kidney.de/pget.php?&tw=1&pmid=22996662 #FOAvip Influenza viruses (IVs) cause pneumonia in humans with progression to lung failure. Pulmonary DCs are key players in the antiviral immune response, which is crucial to restore alveolar barrier function. The mechanisms of expansion and activation of pulmonary DC populations in lung infection remain widely elusive. Using mouse BM chimeric and cell-specific depletion approaches, we demonstrated that alveolar epithelial cell (AEC) GM-CSF mediates recovery from IV-induced injury by affecting lung DC function. Epithelial GM-CSF induced the recruitment of CD11b+ and monocyte-derived DCs. GM-CSF was also required for the presence of CD103+ DCs in the lung parenchyma at baseline and for their sufficient activation and migration to the draining mediastinal lymph nodes (MLNs) during IV infection. These activated CD103+ DCs were indispensable for sufficient clearance of IVs by CD8+ T cells and for recovery from IV-induced lung injury. Moreover, GM-CSF applied intratracheally activated CD103+ DCs, inducing increased migration to MLNs, enhanced viral clearance, and attenuated lung injury. Together, our data reveal that GM-CSF?dependent cross-talk between IV-infected AECs and CD103+ DCs is crucial for effective viral clearance and recovery from injury, which has potential implications for GM-CSF treatment in severe IV pneumonia. Twit Text FOAVip Alveolar epithelial cells orchestrate DC function in murine viral pneumonia ????J Clin Invest http://www.kidney.de/pget.php?&tw=1&pmid=22996662 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=22996662 #FOAvip English Wikipedia <ref>{{Cite pmid|22996662}}</ref> Alveolar epithelial cells orchestrate DC function in murine viral pneumonia #MMPMID22996662 Unkel B; Hoegner K; Clausen BE; Lewe-Schlosser P; Bodner J; Gattenloehner S; Janßen H; Seeger W; Lohmeyer J; Herold S J Clin Invest 2012[Oct]; 122 (10): 3652-64 PMID22996662show ga Influenza viruses (IVs) cause pneumonia in humans with progression to lung failure. Pulmonary DCs are key players in the antiviral immune response, which is crucial to restore alveolar barrier function. The mechanisms of expansion and activation of pulmonary DC populations in lung infection remain widely elusive. Using mouse BM chimeric and cell-specific depletion approaches, we demonstrated that alveolar epithelial cell (AEC) GM-CSF mediates recovery from IV-induced injury by affecting lung DC function. Epithelial GM-CSF induced the recruitment of CD11b+ and monocyte-derived DCs. GM-CSF was also required for the presence of CD103+ DCs in the lung parenchyma at baseline and for their sufficient activation and migration to the draining mediastinal lymph nodes (MLNs) during IV infection. These activated CD103+ DCs were indispensable for sufficient clearance of IVs by CD8+ T cells and for recovery from IV-induced lung injury. Moreover, GM-CSF applied intratracheally activated CD103+ DCs, inducing increased migration to MLNs, enhanced viral clearance, and attenuated lung injury. Together, our data reveal that GM-CSF?dependent cross-talk between IV-infected AECs and CD103+ DCs is crucial for effective viral clearance and recovery from injury, which has potential implications for GM-CSF treatment in severe IV pneumonia. äAlveolar epithelial cells orchestrate DC function in murine viral pneu(epmc).pdf DeepDyve Pubget Overpricing