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Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Nat+Immunol 2010 ; 11 (5): 427-34 Nephropedia Template TP
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Capture of influenza by medullary dendritic cells via SIGN-R1 is essential for humoral immunity in draining lymph nodes #MMPMID20305659
Gonzalez SF; Lukacs-Kornek V; Kuligowski MP; Pitcher LA; Degn SE; Kim YA; Cloninger MJ; Martinez-Pomares L; Gordon S; Turley SJ; Carroll MC
Nat Immunol 2010[May]; 11 (5): 427-34 PMID20305659show ga
A major pathway for B cell acquisition of lymph-borne particulate antigens relies on antigen capture by subcapsular sinus macrophages of the lymph node. Here we tested whether this mechanism is also important for humoral immunity to inactivated influenza virus. By multiple approaches, including multiphoton intravital imaging, we found that antigen capture by sinus-lining macrophages was important for limiting the systemic spread of virus but not for the generation of influenza-specific humoral immunity. Instead, we found that dendritic cells residing in the lymph node medulla use the lectin receptor SIGN-R1 to capture lymph-borne influenza virus and promote humoral immunity. Thus, our results have important implications for the generation of durable humoral immunity to viral pathogens through vaccination.