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10.1038/ni.1856 http://scihub22266oqcxt.onion/10.1038/ni.1856 C3424101!3424101 !20305659     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=20305659 &cmd=llinks): Failed to open stream: HTTP request failed! 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Capture of influenza by medullary dendritic cells via SIGN-R1 is essential for humoral immunity in draining lymph nodes |pdf=|usr=}}{{20305659 }} gab.com Text Capture of influenza by medullary dendritic cells via SIGN-R1 is essential for humoral immunity in draining lymph nodes JO: Nat Immunol http://www.kidney.de/pget.php?&tw=1&pmid=20305659 #FOAvip A major pathway for B cell acquisition of lymph-borne particulate antigens relies on antigen capture by subcapsular sinus macrophages of the lymph node. Here we tested whether this mechanism is also important for humoral immunity to inactivated influenza virus. By multiple approaches, including multiphoton intravital imaging, we found that antigen capture by sinus-lining macrophages was important for limiting the systemic spread of virus but not for the generation of influenza-specific humoral immunity. Instead, we found that dendritic cells residing in the lymph node medulla use the lectin receptor SIGN-R1 to capture lymph-borne influenza virus and promote humoral immunity. Thus, our results have important implications for the generation of durable humoral immunity to viral pathogens through vaccination. Twit Text FOAVip Capture of influenza by medullary dendritic cells via SIGN-R1 is essential for humoral immunity in draining lymph nodes ????Nat Immunol http://www.kidney.de/pget.php?&tw=1&pmid=20305659 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=20305659 #FOAvip English Wikipedia <ref>{{Cite pmid|20305659 }}</ref> Capture of influenza by medullary dendritic cells via SIGN-R1 is essential for humoral immunity in draining lymph nodes #MMPMID20305659 Gonzalez SF ; Lukacs-Kornek V ; Kuligowski MP ; Pitcher LA ; Degn SE ; Kim YA ; Cloninger MJ ; Martinez-Pomares L ; Gordon S ; Turley SJ ; Carroll MC Nat Immunol 2010[May]; 11 (5 ): 427-34 PMID20305659 show ga A major pathway for B cell acquisition of lymph-borne particulate antigens relies on antigen capture by subcapsular sinus macrophages of the lymph node. Here we tested whether this mechanism is also important for humoral immunity to inactivated influenza virus. By multiple approaches, including multiphoton intravital imaging, we found that antigen capture by sinus-lining macrophages was important for limiting the systemic spread of virus but not for the generation of influenza-specific humoral immunity. Instead, we found that dendritic cells residing in the lymph node medulla use the lectin receptor SIGN-R1 to capture lymph-borne influenza virus and promote humoral immunity. Thus, our results have important implications for the generation of durable humoral immunity to viral pathogens through vaccination. |*Endocytosis/drug effects/genetics [MESH] |Animals [MESH] |Antibodies, Viral/blood [MESH] |Antigen Presentation [MESH] |Cell Adhesion Molecules/genetics/immunology/*metabolism [MESH] |Cell Movement [MESH] |Cells, Cultured [MESH] |Clodronic Acid/administration & dosage [MESH] |Dendrimers/administration & dosage [MESH] |Dendritic Cells/drug effects/immunology/*metabolism/pathology/virology [MESH] |Immunity, Humoral/drug effects/genetics [MESH] |Immunoglobulin Heavy Chains/genetics [MESH] |Immunotherapy, Active [MESH] |Influenza A virus/*immunology/pathogenicity [MESH] |Influenza Vaccines/administration & dosage [MESH] |Lectins, C-Type/genetics/immunology/*metabolism [MESH] |Lymph Nodes/pathology/virology [MESH] |Macrophages/drug effects/immunology/*metabolism/pathology/virology [MESH] |Mannose-Binding Lectin/genetics/metabolism [MESH] |Mice [MESH] |Mice, Knockout [MESH] |Mice, Transgenic [MESH] |Microscopy, Fluorescence, Multiphoton [MESH] |Orthomyxoviridae Infections/immunology/prevention & control [MESH]Capture of influenza by medullary dendritic cells via SIGN-R1 is essen(epmc).pdf DeepDyve Pubget Overpricing