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10.1038/ni.2045 http://scihub22266oqcxt.onion/10.1038/ni.2045 C3417123!3417123 !21623379     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\21623379 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Nat+Immunol 2011 ; 12 (7 ): 631-8 Nephropedia Template TP {{tp|p=21623379 |t=2011. Innate lymphoid cells mediate influenza-induced airway hyper-reactivity independently of adaptive immunity |pdf=|usr=}}{{21623379 }} gab.com Text Innate lymphoid cells mediate influenza-induced airway hyper-reactivity independently of adaptive immunity JO: Nat Immunol http://www.kidney.de/pget.php?&tw=1&pmid=21623379 #FOAvip Patients with asthma, a major public health problem, are at high risk for serious disease from influenza virus infection, but the pathogenic mechanisms by which influenza A causes airway disease and asthma are not fully known. We show here in a mouse model that influenza infection acutely induced airway hyper-reactivity (AHR), a cardinal feature of asthma, independently of T helper type 2 (T(H)2) cells and adaptive immunity. Instead, influenza infection induced AHR through a previously unknown pathway that required the interleukin 13 (IL-13)-IL-33 axis and cells of the non-T cell, non-B cell innate lymphoid type called 'natural helper cells'. Infection with influenza A virus, which activates the NLRP3 inflammasome, resulted in much more production of IL-33 by alveolar macrophages, which in turn activated natural helper cells producing substantial IL-13. Twit Text FOAVip Innate lymphoid cells mediate influenza-induced airway hyper-reactivity independently of adaptive immunity ????Nat Immunol http://www.kidney.de/pget.php?&tw=1&pmid=21623379 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=21623379 #FOAvip English Wikipedia <ref>{{Cite pmid|21623379 }}</ref> Innate lymphoid cells mediate influenza-induced airway hyper-reactivity independently of adaptive immunity #MMPMID21623379 Chang YJ ; Kim HY ; Albacker LA ; Baumgarth N ; McKenzie AN ; Smith DE ; Dekruyff RH ; Umetsu DT Nat Immunol 2011[May]; 12 (7 ): 631-8 PMID21623379 show ga Patients with asthma, a major public health problem, are at high risk for serious disease from influenza virus infection, but the pathogenic mechanisms by which influenza A causes airway disease and asthma are not fully known. We show here in a mouse model that influenza infection acutely induced airway hyper-reactivity (AHR), a cardinal feature of asthma, independently of T helper type 2 (T(H)2) cells and adaptive immunity. Instead, influenza infection induced AHR through a previously unknown pathway that required the interleukin 13 (IL-13)-IL-33 axis and cells of the non-T cell, non-B cell innate lymphoid type called 'natural helper cells'. Infection with influenza A virus, which activates the NLRP3 inflammasome, resulted in much more production of IL-33 by alveolar macrophages, which in turn activated natural helper cells producing substantial IL-13. |*Adaptive Immunity [MESH] |Animals [MESH] |Asthma/immunology/physiopathology [MESH] |Bronchial Hyperreactivity/*immunology [MESH] |Carrier Proteins/immunology [MESH] |Female [MESH] |Immunity, Innate [MESH] |Influenza A virus/immunology [MESH] |Interleukin-13/immunology [MESH] |Interleukin-33 [MESH] |Interleukins/immunology [MESH] |Lymphocytes/*immunology [MESH] |Macrophages, Alveolar/immunology [MESH] |Mice [MESH] |Mice, Inbred BALB C [MESH] |NLR Family, Pyrin Domain-Containing 3 Protein [MESH] |Orthomyxoviridae Infections/*immunology [MESH]Innate lymphoid cells mediate influenza-induced airway hyper-reactivit(epmc).pdf DeepDyve Pubget Overpricing