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10.1021/pr3001332 http://scihub22266oqcxt.onion/10.1021/pr3001332 C3412919!3412919 !22709384     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\22709384 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Proteome+Res 2012 ; 11 (8 ): 4091-101 Nephropedia Template TP {{tp|p=22709384 |t=2012. Proteome alterations in primary human alveolar macrophages in response to influenza A virus infection |pdf=|usr=}}{{22709384 }} gab.com Text Proteome alterations in primary human alveolar macrophages in response to influenza A virus infection JO: J Proteome Res http://www.kidney.de/pget.php?&tw=1&pmid=22709384 #FOAvip To obtain a global picture of how alveolar macrophages respond to influenza A virus (IAV) infection, we used a quantitative proteomics method to systematically examine protein expression in the IAV-infected primary human alveolar macrophages. Of the 1214 proteins identified, 43 were significantly up-regulated and 63 significantly down-regulated at >95% confidence. The expression of an array of interferon (IFN)-induced proteins was significantly increased in the IAV-infected macrophages. The protein with the greatest expression increase was ISG15, an IFN-induced protein that has been shown to play an important role in antiviral defense. Concomitantly, quantitative real-time PCR analysis revealed that the gene expression of type I IFNs increased substantially following virus infection. Our results are consistent with the notion that type I IFNs play a vital role in the response of human alveolar macrophages to IAV infection. In addition to the IFN-mediated responses, inflammatory response, apoptosis, and redox state rebalancing appeared also to be major pathways that were affected by IAV infection. Furthermore, our data suggest that alveolar macrophages may play a crucial role in regenerating alveolar epithelium during IAV infection. Twit Text FOAVip Proteome alterations in primary human alveolar macrophages in response to influenza A virus infection ????J Proteome Res http://www.kidney.de/pget.php?&tw=1&pmid=22709384 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=22709384 #FOAvip English Wikipedia <ref>{{Cite pmid|22709384 }}</ref> Proteome alterations in primary human alveolar macrophages in response to influenza A virus infection #MMPMID22709384 Liu L ; Zhou J ; Wang Y ; Mason RJ ; Funk CJ ; Du Y J Proteome Res 2012[Aug]; 11 (8 ): 4091-101 PMID22709384 show ga To obtain a global picture of how alveolar macrophages respond to influenza A virus (IAV) infection, we used a quantitative proteomics method to systematically examine protein expression in the IAV-infected primary human alveolar macrophages. Of the 1214 proteins identified, 43 were significantly up-regulated and 63 significantly down-regulated at >95% confidence. The expression of an array of interferon (IFN)-induced proteins was significantly increased in the IAV-infected macrophages. The protein with the greatest expression increase was ISG15, an IFN-induced protein that has been shown to play an important role in antiviral defense. Concomitantly, quantitative real-time PCR analysis revealed that the gene expression of type I IFNs increased substantially following virus infection. Our results are consistent with the notion that type I IFNs play a vital role in the response of human alveolar macrophages to IAV infection. In addition to the IFN-mediated responses, inflammatory response, apoptosis, and redox state rebalancing appeared also to be major pathways that were affected by IAV infection. Furthermore, our data suggest that alveolar macrophages may play a crucial role in regenerating alveolar epithelium during IAV infection. |Cells, Cultured [MESH] |Gene Expression [MESH] |Gene Expression Regulation [MESH] |Host-Pathogen Interactions [MESH] |Humans [MESH] |Immunity, Innate [MESH] |Influenza A Virus, H1N1 Subtype/immunology/*physiology [MESH] |Influenza, Human/immunology/*metabolism [MESH] |Interferon Type I/metabolism [MESH] |Macrophages, Alveolar/immunology/*metabolism/virology [MESH] |Primary Cell Culture [MESH] |Protein Interaction Maps [MESH] |Proteome/genetics/*metabolism [MESH]Proteome alterations in primary human alveolar macrophages in response(epmc).pdf DeepDyve Pubget Overpricing