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10.1016/j.toxicon.2011.07.016 http://scihub22266oqcxt.onion/10.1016/j.toxicon.2011.07.016 C3397671!3397671!21867724     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Toxicon 2012 ; 59 (4): 529-46 Nephropedia Template TP {{tp|p=21867724|t=2012. Development of a sea anemone toxin as an immunomodulator for therapy of autoimmune diseases |pdf=|usr=}}{{21867724}} gab.com Text Development of a sea anemone toxin as an immunomodulator for therapy of autoimmune diseases JO: Toxicon http://www.kidney.de/pget.php?&tw=1&pmid=21867724 #FOAvip Electrophysiological and pharmacological studies coupled with molecular identification have revealed a unique network of ion channels?Kv1.3, KCa3.1, CRAC (Orai1 + Stim1), TRPM7, Clswell?in lymphocytes that initiates and maintains the calcium signaling cascade required for activation. The expression pattern of these channels changes during lymphocyte activation and differentiation, allowing the functional network to adapt during an immune response. The Kv1.3 channel is of interest because it plays a critical role in subsets of T and B lymphocytes implicated in autoimmune disorders. The ShK toxin from the sea anemone Stichodactyla helianthus is a potent blocker of Kv1.3. ShK-186, a synthetic analog of ShK, is being developed as a therapeutic for autoimmune diseases, and is scheduled to begin first-in-man phase-1 trials in 2011. This review describes the journey that has led to the development of ShK-186. Twit Text FOAVip Development of a sea anemone toxin as an immunomodulator for therapy of autoimmune diseases ????Toxicon http://www.kidney.de/pget.php?&tw=1&pmid=21867724 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=21867724 #FOAvip English Wikipedia <ref>{{Cite pmid|21867724}}</ref> Development of a sea anemone toxin as an immunomodulator for therapy of autoimmune diseases #MMPMID21867724 Chi V; Pennington MW; Norton RS; Tarcha E; Londono L; Sims-Fahey B; Upadhyay SK; Lakey JT; Iadonato S; Wulff H; Beeton C; Chandy KG Toxicon 2012[Mar]; 59 (4): 529-46 PMID21867724show ga Electrophysiological and pharmacological studies coupled with molecular identification have revealed a unique network of ion channels?Kv1.3, KCa3.1, CRAC (Orai1 + Stim1), TRPM7, Clswell?in lymphocytes that initiates and maintains the calcium signaling cascade required for activation. The expression pattern of these channels changes during lymphocyte activation and differentiation, allowing the functional network to adapt during an immune response. The Kv1.3 channel is of interest because it plays a critical role in subsets of T and B lymphocytes implicated in autoimmune disorders. The ShK toxin from the sea anemone Stichodactyla helianthus is a potent blocker of Kv1.3. ShK-186, a synthetic analog of ShK, is being developed as a therapeutic for autoimmune diseases, and is scheduled to begin first-in-man phase-1 trials in 2011. This review describes the journey that has led to the development of ShK-186. äDevelopment of a sea anemone toxin as an immunomodulator for therapy o(epmc).pdf DeepDyve Pubget Overpricing