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10.1371/journal.pone.0040303 http://scihub22266oqcxt.onion/10.1371/journal.pone.0040303 C3391237!3391237 !22792270     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\22792270 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       PLoS+One 2012 ; 7 (7 ): e40303 Nephropedia Template TP {{tp|p=22792270 |t=2012. Innate immune induction and influenza protection elicited by a response-selective agonist of human C5a |pdf=|usr=}}{{22792270 }} gab.com Text Innate immune induction and influenza protection elicited by a response-selective agonist of human C5a JO: PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=22792270 #FOAvip The anaphylatoxin C5a is an especially potent mediator of both local and systemic inflammation. However, C5a also plays an essential role in mucosal host defense against bacterial, viral, and fungal infection. We have developed a response-selective agonist of human C5a, termed EP67, which retains the immunoenhancing activity of C5a at the expense of its inflammatory, anaphylagenic properties. EP67 insufflation results in the rapid induction of pulmonary cytokines and chemokines. This is followed by an influx of innate immune effector cells, including neutrophils, NK cells, and dendritic cells. EP67 exhibits both prophylactic and therapeutic protection when tested in a murine model of influenza A infection. Mice treated with EP67 within a twenty-four hour window of non-lethal infection were significantly protected from influenza-induced weight loss. Furthermore, EP67 delivered twenty-four hours after lethal infection completely blocked influenza-induced mortality (0% vs. 100% survival). Since protection based on innate immune induction is not restricted to any specific pathogen, EP67 may well prove equally efficacious against a wide variety of possible viral, bacterial, and fungal pathogens. Such a strategy could be used to stop the worldwide spread of emergent respiratory diseases, including but not limited to novel strains of influenza. Twit Text FOAVip Innate immune induction and influenza protection elicited by a response-selective agonist of human C5a ????PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=22792270 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=22792270 #FOAvip English Wikipedia <ref>{{Cite pmid|22792270 }}</ref> Innate immune induction and influenza protection elicited by a response-selective agonist of human C5a #MMPMID22792270 Sanderson SD ; Thoman ML ; Kis K ; Virts EL ; Herrera EB ; Widmann S ; Sepulveda H ; Phillips JA PLoS One 2012[]; 7 (7 ): e40303 PMID22792270 show ga The anaphylatoxin C5a is an especially potent mediator of both local and systemic inflammation. However, C5a also plays an essential role in mucosal host defense against bacterial, viral, and fungal infection. We have developed a response-selective agonist of human C5a, termed EP67, which retains the immunoenhancing activity of C5a at the expense of its inflammatory, anaphylagenic properties. EP67 insufflation results in the rapid induction of pulmonary cytokines and chemokines. This is followed by an influx of innate immune effector cells, including neutrophils, NK cells, and dendritic cells. EP67 exhibits both prophylactic and therapeutic protection when tested in a murine model of influenza A infection. Mice treated with EP67 within a twenty-four hour window of non-lethal infection were significantly protected from influenza-induced weight loss. Furthermore, EP67 delivered twenty-four hours after lethal infection completely blocked influenza-induced mortality (0% vs. 100% survival). Since protection based on innate immune induction is not restricted to any specific pathogen, EP67 may well prove equally efficacious against a wide variety of possible viral, bacterial, and fungal pathogens. Such a strategy could be used to stop the worldwide spread of emergent respiratory diseases, including but not limited to novel strains of influenza. |Animals [MESH] |Antigen-Presenting Cells/immunology/virology [MESH] |Chemokines/metabolism [MESH] |Complement C5a/*agonists [MESH] |Cytokines/metabolism [MESH] |Dose-Response Relationship, Drug [MESH] |Female [MESH] |Humans [MESH] |Immunity, Innate/*drug effects [MESH] |Immunologic Factors/*administration & dosage [MESH] |Influenza A virus/*immunology [MESH] |Influenza, Human/immunology/*prevention & control [MESH] |Insufflation [MESH] |Kinetics [MESH] |Lung/immunology/metabolism/pathology/virology [MESH] |Macrophages, Alveolar/immunology/virology [MESH] |Male [MESH] |Mice [MESH] |Mice, Inbred C57BL [MESH]Innate immune induction and influenza protection elicited by a respons(epmc).pdf DeepDyve Pubget Overpricing