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10.1189/jlb.0911479 http://scihub22266oqcxt.onion/10.1189/jlb.0911479 C3382316!3382316 !22442495     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=22442495 &cmd=llinks): Failed to open stream: HTTP request failed! 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Highly pathogenic avian influenza viruses inhibit effective immune responses of human blood-derived macrophages |pdf=|usr=}}{{22442495 }} gab.com Text Highly pathogenic avian influenza viruses inhibit effective immune responses of human blood-derived macrophages JO: J Leukoc Biol http://www.kidney.de/pget.php?&tw=1&pmid=22442495 #FOAvip Systemic infections with HPAIVs, such as H5N1, are characterized by cytokine burst and sepsis. We investigated the role of human monocyte-derived macrophages in these events after infection with different influenza virus strains. Macrophages were infected with low pathogenic H1N1 (PR8) or high pathogenic H7N7 (FPV) and H5N1 (KAN-1) subtypes. Macrophages were found to be nonpermissive for influenza virus propagation. Surprisingly, transcriptome analysis revealed an insufficient innate immune response of macrophages only to HPAIV infections. Induction of inflammatory cytokines, as well as type I IFNs, was significantly attenuated in H5N1- and H7N7-infected cells, contradicting a primary role of macrophages for the cytokine burst. Furthermore, inflammasome activation was impaired significantly in HPAIV-infected macrophages. Interestingly, this finding correlated with a complete suppression of viral protein M2 expression after HPAIV infection, which is known to be involved in influenza viral inflammasome activation. In summary, our data provide first evidences for a strategy of how HPAIVs avoid initial inflammatory responses of macrophages facilitating virus spreading and progression to the systemic stage of disease. Twit Text FOAVip Highly pathogenic avian influenza viruses inhibit effective immune responses of human blood-derived macrophages ????J Leukoc Biol http://www.kidney.de/pget.php?&tw=1&pmid=22442495 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=22442495 #FOAvip English Wikipedia <ref>{{Cite pmid|22442495 }}</ref> Highly pathogenic avian influenza viruses inhibit effective immune responses of human blood-derived macrophages #MMPMID22442495 Friesenhagen J ; Boergeling Y ; Hrincius E ; Ludwig S ; Roth J ; Viemann D J Leukoc Biol 2012[Jul]; 92 (1 ): 11-20 PMID22442495 show ga Systemic infections with HPAIVs, such as H5N1, are characterized by cytokine burst and sepsis. We investigated the role of human monocyte-derived macrophages in these events after infection with different influenza virus strains. Macrophages were infected with low pathogenic H1N1 (PR8) or high pathogenic H7N7 (FPV) and H5N1 (KAN-1) subtypes. Macrophages were found to be nonpermissive for influenza virus propagation. Surprisingly, transcriptome analysis revealed an insufficient innate immune response of macrophages only to HPAIV infections. Induction of inflammatory cytokines, as well as type I IFNs, was significantly attenuated in H5N1- and H7N7-infected cells, contradicting a primary role of macrophages for the cytokine burst. Furthermore, inflammasome activation was impaired significantly in HPAIV-infected macrophages. Interestingly, this finding correlated with a complete suppression of viral protein M2 expression after HPAIV infection, which is known to be involved in influenza viral inflammasome activation. In summary, our data provide first evidences for a strategy of how HPAIVs avoid initial inflammatory responses of macrophages facilitating virus spreading and progression to the systemic stage of disease. |*Immunity, Innate [MESH] |Animals [MESH] |Biomarkers/metabolism [MESH] |Blotting, Western [MESH] |Cells, Cultured [MESH] |Cytokines/metabolism [MESH] |Flow Cytometry [MESH] |Fluorescent Antibody Technique [MESH] |Gene Expression Profiling [MESH] |Humans [MESH] |Immunoenzyme Techniques [MESH] |Influenza A Virus, H1N1 Subtype/*pathogenicity [MESH] |Influenza A Virus, H5N1 Subtype/*pathogenicity [MESH] |Influenza A Virus, H7N7 Subtype/*pathogenicity [MESH] |Influenza, Human/*immunology/virology [MESH] |Macrophages/*immunology/virology [MESH] |Monocytes/immunology/virology [MESH] |Oligonucleotide Array Sequence Analysis [MESH] |Orthomyxoviridae Infections/genetics/*immunology/virology [MESH] |RNA, Messenger/genetics [MESH] |Real-Time Polymerase Chain Reaction [MESH] |Reverse Transcriptase Polymerase Chain Reaction [MESH] |Viral Matrix Proteins/genetics/metabolism [MESH]Highly pathogenic avian influenza viruses inhibit effective immune res(epmc).pdf DeepDyve Pubget Overpricing