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10.1016/j.ijcard.2011.11.032 http://scihub22266oqcxt.onion/10.1016/j.ijcard.2011.11.032 C3310957!3310957!22178059     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Int+J+Cardiol 2013 ; 166 (2): 499-504 Nephropedia Template TP {{tp|p=22178059|t=2013. MASP-2 Activation is Involved in Ischemia-related Necrotic Myocardial Injury in Humans |pdf=|usr=}}{{22178059}} gab.com Text MASP-2 Activation is Involved in Ischemia-related Necrotic Myocardial Injury in Humans JO: Int J Cardiol http://www.kidney.de/pget.php?&tw=1&pmid=22178059 #FOAvip Background/Objectives: Insufficient blood supply to the heart results in ischemic injury manifested clinically as myocardial infarction (MI). Following ischemia, inflammation is provoked and related to the clinical outcomes. A recent basic science study indicates that complement factor MASP-2 plays an important role in animal models of ischemia/reperfusion injury. We investigated the role of MASP-2 in human acute myocardial ischemia in two clinical settings: (1) Acute MI, and (2) Open heart surgery. Methods: A total of 187 human subjects were enrolled in this study, including 50 healthy individuals, 27 patients who were diagnosed of coronary artery disease (CAD) but without acute MI, 29 patients with acute MI referred for coronary angiography, and 81 cardiac surgery patients with surgically-induced global heart ischemia. Circulating MASP-2 levels were measured by ELISA. Results: MASP-2 levels in the peripheral circulation were significantly reduced in MI patients compared with those of healthy individuals or of CAD patients without acute MI. The hypothesis that MASP-2 was activated during acute myocardial ischemia was evaluated in cardiac patients undergoing surgically-induced global heart ischemia. MASP-2 was found to be significantly reduced in the coronary circulation of such patients, and the reduction of MASP-2 levels correlated independently with the increase of the myocardial necrosis marker, cardiac troponin I. Conclusions: These results indicate an involvement of MASP-2 in ischemia-related necrotic myocardial injury in humans. Twit Text FOAVip MASP-2 Activation is Involved in Ischemia-related Necrotic Myocardial Injury in Humans ????Int J Cardiol http://www.kidney.de/pget.php?&tw=1&pmid=22178059 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=22178059 #FOAvip English Wikipedia <ref>{{Cite pmid|22178059}}</ref> MASP-2 Activation is Involved in Ischemia-related Necrotic Myocardial Injury in Humans #MMPMID22178059 Zhang M; Hou Y; Cavusoglu E; Lee DC; Steffensen R; Yang L; Bashari D; Villamil J; Moussa M; Fernaine G; Jensenius JC; Marmur JD; Ko W; Shevde K Int J Cardiol 2013[Jun]; 166 (2): 499-504 PMID22178059show ga Background/Objectives: Insufficient blood supply to the heart results in ischemic injury manifested clinically as myocardial infarction (MI). Following ischemia, inflammation is provoked and related to the clinical outcomes. A recent basic science study indicates that complement factor MASP-2 plays an important role in animal models of ischemia/reperfusion injury. We investigated the role of MASP-2 in human acute myocardial ischemia in two clinical settings: (1) Acute MI, and (2) Open heart surgery. Methods: A total of 187 human subjects were enrolled in this study, including 50 healthy individuals, 27 patients who were diagnosed of coronary artery disease (CAD) but without acute MI, 29 patients with acute MI referred for coronary angiography, and 81 cardiac surgery patients with surgically-induced global heart ischemia. Circulating MASP-2 levels were measured by ELISA. Results: MASP-2 levels in the peripheral circulation were significantly reduced in MI patients compared with those of healthy individuals or of CAD patients without acute MI. The hypothesis that MASP-2 was activated during acute myocardial ischemia was evaluated in cardiac patients undergoing surgically-induced global heart ischemia. MASP-2 was found to be significantly reduced in the coronary circulation of such patients, and the reduction of MASP-2 levels correlated independently with the increase of the myocardial necrosis marker, cardiac troponin I. Conclusions: These results indicate an involvement of MASP-2 in ischemia-related necrotic myocardial injury in humans. äMASP-2 Activation is Involved in Ischemia-related Necrotic Myocardial (epmc).pdf DeepDyve Pubget Overpricing