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10.1128/JVI.05663-11 http://scihub22266oqcxt.onion/10.1128/JVI.05663-11 C3302287!3302287!22190725     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=22190725&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Virol 2012 ; 86 (5): 2512-22 Nephropedia Template TP {{tp|p=22190725|t=2012. Borna Disease Virus Infects Human Neural Progenitor Cells and Impairs Neurogenesis |pdf=|usr=}}{{22190725}} gab.com Text Borna Disease Virus Infects Human Neural Progenitor Cells and Impairs Neurogenesis JO: J Virol http://www.kidney.de/pget.php?&tw=1&pmid=22190725 #FOAvip Understanding the complex mechanisms by which infectious agents can disrupt behavior represents a major challenge. The Borna disease virus (BDV), a potential human pathogen, provides a unique model to study such mechanisms. Because BDV induces neurodegeneration in brain areas that are still undergoing maturation at the time of infection, we tested the hypothesis that BDV interferes with neurogenesis. We showed that human neural stem/progenitor cells are highly permissive to BDV, although infection does not alter their survival or undifferentiated phenotype. In contrast, upon the induction of differentiation, BDV is capable of severely impairing neurogenesis by interfering with the survival of newly generated neurons. Such impairment was specific to neurogenesis, since astrogliogenesis was unaltered. In conclusion, we demonstrate a new mechanism by which BDV might impair neural function and brain plasticity in infected individuals. These results may contribute to a better understanding of behavioral disorders associated with BDV infection. Twit Text FOAVip Borna Disease Virus Infects Human Neural Progenitor Cells and Impairs Neurogenesis ????J Virol http://www.kidney.de/pget.php?&tw=1&pmid=22190725 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=22190725 #FOAvip English Wikipedia <ref>{{Cite pmid|22190725}}</ref> Borna Disease Virus Infects Human Neural Progenitor Cells and Impairs Neurogenesis #MMPMID22190725 Brnic D; Stevanovic V; Cochet M; Agier C; Richardson J; Montero-Menei CN; Milhavet O; Eloit M; Coulpier M J Virol 2012[Mar]; 86 (5): 2512-22 PMID22190725show ga Understanding the complex mechanisms by which infectious agents can disrupt behavior represents a major challenge. The Borna disease virus (BDV), a potential human pathogen, provides a unique model to study such mechanisms. Because BDV induces neurodegeneration in brain areas that are still undergoing maturation at the time of infection, we tested the hypothesis that BDV interferes with neurogenesis. We showed that human neural stem/progenitor cells are highly permissive to BDV, although infection does not alter their survival or undifferentiated phenotype. In contrast, upon the induction of differentiation, BDV is capable of severely impairing neurogenesis by interfering with the survival of newly generated neurons. Such impairment was specific to neurogenesis, since astrogliogenesis was unaltered. In conclusion, we demonstrate a new mechanism by which BDV might impair neural function and brain plasticity in infected individuals. These results may contribute to a better understanding of behavioral disorders associated with BDV infection. äBorna Disease Virus Infects Human Neural Progenitor Cells and Impairs (epmc).pdf DeepDyve Pubget Overpricing