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10.4049/jimmunol.1101335 http://scihub22266oqcxt.onion/10.4049/jimmunol.1101335 C3294087!3294087!22345650     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Immunol 2012 ; 188 (6): 2759-68 Nephropedia Template TP {{tp|p=22345650|t=2012. Hapivirins and Diprovirins: Novel ?-Defensin Analogs With Potent Activity Against Influenza A Virusa |pdf=|usr=}}{{22345650}} gab.com Text Hapivirins and Diprovirins: Novel -Defensin Analogs With Potent Activity Against Influenza A Virusa JO: J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=22345650 #FOAvip ?-defensins are cyclic octadecapeptides found in non-human primates whose broad antiviral-spectrum includes HIV-1, HSV-1, SARS, and influenza A virus (IAV). We previously reported that synthetic ?-defensins called retrocyclins can neutralize and aggregate various strains of IAV and increase IAV uptake by neutrophils. This report describes two families of peptides, hapivirins (HpVs) and diprovirins (DpVs), whose design was inspired by retrocyclins. The goal was to develop smaller partially cyclic peptides that retain the antiviral activity of retrocyclins, while being easier to synthesize. The novel peptides also allowed for systemic substitution of key residues to evaluate the role of charge or hydrophobicity on antiviral activity. Seventy-two HpV or DpV peptides are described in this report, including several whose anti-IAV activity equals or exceeds that of normal ?? or ?-defensins. Some of these also had strong antibacterial and antifungal activity. These new peptides were active against H3N2 and H1N1 strains of IAV. Structural features imparting strong antiviral activity were identified through iterative cycles of synthesis and testing. Our findings show the importance of hydrophobic residues for antiviral activity and show that pegylation, which often increases a peptide?s serum half-life in vivo, can increase the antiviral activity of DpVs. The new peptides acted at an early phase of viral infection and when combined with pulmonary surfactant protein D, their antiviral effects were additive. The peptides strongly increased neutrophil and macrophage uptake of IAV, while inhibiting monocyte cytokine generation. Development of modified ?? defensin analogues provides an approach for creating novel antiviral agents for IAV infections. Twit Text FOAVip Hapivirins and Diprovirins: Novel -Defensin Analogs With Potent Activity Against Influenza A Virusa ????J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=22345650 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=22345650 #FOAvip English Wikipedia <ref>{{Cite pmid|22345650}}</ref> Hapivirins and Diprovirins: Novel ?-Defensin Analogs With Potent Activity Against Influenza A Virusa #MMPMID22345650 Doss M; Ruchala P; Tecle T; Gantz D; Verma A; Hartshorn A; Crouch EC; Luong H; Micewicz ED; Lehrer RI; Hartshorn KL J Immunol 2012[Mar]; 188 (6): 2759-68 PMID22345650show ga ?-defensins are cyclic octadecapeptides found in non-human primates whose broad antiviral-spectrum includes HIV-1, HSV-1, SARS, and influenza A virus (IAV). We previously reported that synthetic ?-defensins called retrocyclins can neutralize and aggregate various strains of IAV and increase IAV uptake by neutrophils. This report describes two families of peptides, hapivirins (HpVs) and diprovirins (DpVs), whose design was inspired by retrocyclins. The goal was to develop smaller partially cyclic peptides that retain the antiviral activity of retrocyclins, while being easier to synthesize. The novel peptides also allowed for systemic substitution of key residues to evaluate the role of charge or hydrophobicity on antiviral activity. Seventy-two HpV or DpV peptides are described in this report, including several whose anti-IAV activity equals or exceeds that of normal ?? or ?-defensins. Some of these also had strong antibacterial and antifungal activity. These new peptides were active against H3N2 and H1N1 strains of IAV. Structural features imparting strong antiviral activity were identified through iterative cycles of synthesis and testing. Our findings show the importance of hydrophobic residues for antiviral activity and show that pegylation, which often increases a peptide?s serum half-life in vivo, can increase the antiviral activity of DpVs. The new peptides acted at an early phase of viral infection and when combined with pulmonary surfactant protein D, their antiviral effects were additive. The peptides strongly increased neutrophil and macrophage uptake of IAV, while inhibiting monocyte cytokine generation. Development of modified ?? defensin analogues provides an approach for creating novel antiviral agents for IAV infections. äHapivirins and Diprovirins: Novel ?-Defensin Analogs With Potent Activ(epmc).pdf DeepDyve Pubget Overpricing