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10.1186/2110-5820-1-53 http://scihub22266oqcxt.onion/10.1186/2110-5820-1-53 C3264499!3264499 !22208725     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=22208725 &cmd=llinks): Failed to open stream: HTTP request failed! 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Disturbances of the hypothalamic-pituitary-adrenal axis and plasma electrolytes during experimental sepsis |pdf=|usr=}}{{22208725 }} gab.com Text Disturbances of the hypothalamic-pituitary-adrenal axis and plasma electrolytes during experimental sepsis JO: Ann Intensive Care http://www.kidney.de/pget.php?&tw=1&pmid=22208725 #FOAvip BACKGROUND: Sepsis continues to be a poorly understood syndrome with a high mortality rate. While we are beginning to decipher the intricate interplay of the inflammatory response during sepsis, the precise regulation of the hypothalamic-pituitary-adrenal (HPA) axis and its impact on electrolyte homeostasis during sepsis remains incompletely understood. METHODS: Sepsis was induced in adult male Sprague-Dawley rats by cecal ligation and puncture (CLP). Plasma samples were obtained as a function of time (6-48 hrs) after CLP and compared with healthy animals (neg ctrl). Samples were analyzed for adrenocorticotropin (ACTH), corticosterone, and aldosterone levels, as well as concentrations of sodium (Na+), potassium (K+), chloride (Cl-), and magnesium (Mg2+). RESULTS: ACTH levels were found to be significantly reduced 6-24 hrs after CLP in comparison to baseline levels and displayed gradual recovery during the later course (24-48 hrs) of sepsis. Plasma corticosterone concentrations exhibited a bell-shaped response, peaking between 6 and 12 hrs followed by rapid decline and concentrations below negative control levels 48 hrs after injury. Aldosterone levels in septic animals were continuously elevated between 6 and 48 hrs. Whereas plasma Na+ levels were found to be persistently elevated following CLP, levels of K+, Cl- and Mg2+ were significantly reduced as a function of time and gradually recovered during the later course of sepsis. CONCLUSIONS: CLP-induced sepsis resulted in dynamic changes of ACTH, corticosterone, and aldosterone levels. In addition, electrolyte levels showed significant disturbances after CLP. These electrolyte perturbations might be evoked by a downstream effect or a dysfunctional HPA-axis response during sepsis and contribute to severe complications during sepsis. Twit Text FOAVip Disturbances of the hypothalamic-pituitary-adrenal axis and plasma electrolytes during experimental sepsis ????Ann Intensive Care http://www.kidney.de/pget.php?&tw=1&pmid=22208725 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=22208725 #FOAvip English Wikipedia <ref>{{Cite pmid|22208725 }}</ref> Disturbances of the hypothalamic-pituitary-adrenal axis and plasma electrolytes during experimental sepsis #MMPMID22208725 Flierl MA ; Rittirsch D ; Weckbach S ; Huber-Lang M ; Ipaktchi K ; Ward PA ; Stahel PF Ann Intensive Care 2011[Dec]; 1 (ä): 53 PMID22208725 show ga BACKGROUND: Sepsis continues to be a poorly understood syndrome with a high mortality rate. While we are beginning to decipher the intricate interplay of the inflammatory response during sepsis, the precise regulation of the hypothalamic-pituitary-adrenal (HPA) axis and its impact on electrolyte homeostasis during sepsis remains incompletely understood. METHODS: Sepsis was induced in adult male Sprague-Dawley rats by cecal ligation and puncture (CLP). Plasma samples were obtained as a function of time (6-48 hrs) after CLP and compared with healthy animals (neg ctrl). Samples were analyzed for adrenocorticotropin (ACTH), corticosterone, and aldosterone levels, as well as concentrations of sodium (Na+), potassium (K+), chloride (Cl-), and magnesium (Mg2+). RESULTS: ACTH levels were found to be significantly reduced 6-24 hrs after CLP in comparison to baseline levels and displayed gradual recovery during the later course (24-48 hrs) of sepsis. Plasma corticosterone concentrations exhibited a bell-shaped response, peaking between 6 and 12 hrs followed by rapid decline and concentrations below negative control levels 48 hrs after injury. Aldosterone levels in septic animals were continuously elevated between 6 and 48 hrs. Whereas plasma Na+ levels were found to be persistently elevated following CLP, levels of K+, Cl- and Mg2+ were significantly reduced as a function of time and gradually recovered during the later course of sepsis. CONCLUSIONS: CLP-induced sepsis resulted in dynamic changes of ACTH, corticosterone, and aldosterone levels. In addition, electrolyte levels showed significant disturbances after CLP. These electrolyte perturbations might be evoked by a downstream effect or a dysfunctional HPA-axis response during sepsis and contribute to severe complications during sepsis. äDisturbances of the hypothalamic-pituitary-adrenal axis and plasma ele(epmc).pdf DeepDyve Pubget Overpricing