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10.1371/journal.pone.0030328 http://scihub22266oqcxt.onion/10.1371/journal.pone.0030328 C3261190!3261190 !22279582     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\22279582 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       PLoS+One 2012 ; 7 (1 ): e30328 Nephropedia Template TP {{tp|p=22279582 |t=2012. Distinct regulation of host responses by ERK and JNK MAP kinases in swine macrophages infected with pandemic (H1N1) 2009 influenza virus |pdf=|usr=}}{{22279582 }} gab.com Text Distinct regulation of host responses by ERK and JNK MAP kinases in swine macrophages infected with pandemic (H1N1) 2009 influenza virus JO: PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=22279582 #FOAvip Swine influenza is an acute respiratory disease in pigs caused by swine influenza virus (SIV). Highly virulent SIV strains cause mortality of up to 10%. Importantly, pigs have long been considered "mixing vessels" that generate novel influenza viruses with pandemic potential, a constant threat to public health. Since its emergence in 2009 and subsequent pandemic spread, the pandemic (H1N1) 2009 (H1N1pdm) has been detected in pig farms, creating the risk of generating new reassortants and their possible infection of humans. Pathogenesis in SIV or H1N1pdm-infected pigs remains poorly characterized. Proinflammatory and antiviral cytokine responses are considered correlated with the intensity of clinical signs, and swine macrophages are found to be indispensible in effective clearance of SIV from pig lungs. In this study, we report a unique pattern of cytokine responses in swine macrophages infected with H1N1pdm. The roles of mitogen-activated protein (MAP) kinases in the regulation of the host responses were examined. We found that proinflammatory cytokines IL-6, IL-8, IL-10, and TNF-? were significantly induced and their induction was ERK1/2-dependent. IFN-? and IFN-inducible antiviral Mx and 2'5'-OAS were sharply induced, but the inductions were effectively abolished when ERK1/2 was inhibited. Induction of CCL5 (RANTES) was completely inhibited by inhibitors of ERK1/2 and JNK1/2, which appeared also to regulate FasL and TNF-?, critical for apoptosis in pig macrophages. We found that NF?B was activated in H1N1pdm-infected cells, but the activation was suppressed when ERK1/2 was inhibited, indicating there is cross-talk between MAP kinase and NF?B responses in pig macrophages. Our data suggest that MAP kinase may activate NF?B through the induction of RIG-1, which leads to the induction of IFN-? in swine macrophages. Understanding host responses and their underlying mechanisms may help identify venues for effective control of SIV and assist in prevention of future influenza pandemics. Twit Text FOAVip Distinct regulation of host responses by ERK and JNK MAP kinases in swine macrophages infected with pandemic (H1N1) 2009 influenza virus ????PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=22279582 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=22279582 #FOAvip English Wikipedia <ref>{{Cite pmid|22279582 }}</ref> Distinct regulation of host responses by ERK and JNK MAP kinases in swine macrophages infected with pandemic (H1N1) 2009 influenza virus #MMPMID22279582 Gao W ; Sun W ; Qu B ; Cardona CJ ; Powell K ; Wegner M ; Shi Y ; Xing Z PLoS One 2012[]; 7 (1 ): e30328 PMID22279582 show ga Swine influenza is an acute respiratory disease in pigs caused by swine influenza virus (SIV). Highly virulent SIV strains cause mortality of up to 10%. Importantly, pigs have long been considered "mixing vessels" that generate novel influenza viruses with pandemic potential, a constant threat to public health. Since its emergence in 2009 and subsequent pandemic spread, the pandemic (H1N1) 2009 (H1N1pdm) has been detected in pig farms, creating the risk of generating new reassortants and their possible infection of humans. Pathogenesis in SIV or H1N1pdm-infected pigs remains poorly characterized. Proinflammatory and antiviral cytokine responses are considered correlated with the intensity of clinical signs, and swine macrophages are found to be indispensible in effective clearance of SIV from pig lungs. In this study, we report a unique pattern of cytokine responses in swine macrophages infected with H1N1pdm. The roles of mitogen-activated protein (MAP) kinases in the regulation of the host responses were examined. We found that proinflammatory cytokines IL-6, IL-8, IL-10, and TNF-? were significantly induced and their induction was ERK1/2-dependent. IFN-? and IFN-inducible antiviral Mx and 2'5'-OAS were sharply induced, but the inductions were effectively abolished when ERK1/2 was inhibited. Induction of CCL5 (RANTES) was completely inhibited by inhibitors of ERK1/2 and JNK1/2, which appeared also to regulate FasL and TNF-?, critical for apoptosis in pig macrophages. We found that NF?B was activated in H1N1pdm-infected cells, but the activation was suppressed when ERK1/2 was inhibited, indicating there is cross-talk between MAP kinase and NF?B responses in pig macrophages. Our data suggest that MAP kinase may activate NF?B through the induction of RIG-1, which leads to the induction of IFN-? in swine macrophages. Understanding host responses and their underlying mechanisms may help identify venues for effective control of SIV and assist in prevention of future influenza pandemics. |Animals [MESH] |Blotting, Western [MESH] |Cell Line [MESH] |Chemokine CCL5/genetics [MESH] |Cytokines/genetics [MESH] |Enzyme Inhibitors/pharmacology [MESH] |Extracellular Signal-Regulated MAP Kinases/antagonists & inhibitors/*metabolism [MESH] |Gene Expression/drug effects [MESH] |Humans [MESH] |Influenza A Virus, H1N1 Subtype/*isolation & purification/physiology [MESH] |JNK Mitogen-Activated Protein Kinases/antagonists & inhibitors/*metabolism [MESH] |Macrophages/drug effects/*metabolism/virology [MESH] |Mitogen-Activated Protein Kinase 1/antagonists & inhibitors/metabolism [MESH] |Mitogen-Activated Protein Kinase 3/antagonists & inhibitors/metabolism [MESH] |Mitogen-Activated Protein Kinase 8/metabolism [MESH] |Mitogen-Activated Protein Kinase 9/metabolism [MESH] |NF-kappa B/metabolism [MESH] |Orthomyxoviridae Infections/epidemiology/veterinary [MESH] |Pandemics [MESH] |Reverse Transcriptase Polymerase Chain Reaction [MESH] |Swine [MESH] |Swine Diseases/epidemiology/virology [MESH]Distinct regulation of host responses by ERK and JNK MAP kinases in sw(epmc).pdf DeepDyve Pubget Overpricing