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10.1007/82_2010_51 http://scihub22266oqcxt.onion/10.1007/82_2010_51 C3244828!3244828!20517723     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Curr+Top+Microbiol+Immunol 2011 ; 344 (ä): 41-59 Nephropedia Template TP {{tp|p=20517723|t=2011. STAT3: A Target to Enhance Antitumor Immune Response |pdf=|usr=}}{{20517723}} gab.com Text STAT3: A Target to Enhance Antitumor Immune Response JO: Curr Top Microbiol Immunol http://www.kidney.de/pget.php?&tw=1&pmid=20517723 #FOAvip Signal transducer and activator of transcription 3 (Stat3) has emerged as a critical regulator for tumor-associated inflammation. Activation of Stat3 negatively regulates the Th1-type immune response and promotes expansion of myeloid-derived suppressor cells (MDSCs) and regulatory T-cell functions in the tumor microenvironment. Mounting evidence suggests that Stat3 and related pathways may serve as a target for changing the tumor immunologic microenvironment to benefit cancer immunotherapies. Many recent studies support the use of certain tyrosine kinase inhibitors, through inhibition of Stat3, in decreasing immunosuppression in the tumor microenvironment. Other potential therapeutic avenues include the use of targeted delivery of Stat3 siRNA into immune cells. Here, we describe the role of Stat3 in regulating the immunologic properties of tumors as a background for Stat3-based therapeutic interventions. Twit Text FOAVip STAT3: A Target to Enhance Antitumor Immune Response ????Curr Top Microbiol Immunol http://www.kidney.de/pget.php?&tw=1&pmid=20517723 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=20517723 #FOAvip English Wikipedia <ref>{{Cite pmid|20517723}}</ref> STAT3: A Target to Enhance Antitumor Immune Response #MMPMID20517723 Lee H; Pal SK; Reckamp K; Figlin RA; Yu H Curr Top Microbiol Immunol 2011[]; 344 (ä): 41-59 PMID20517723show ga Signal transducer and activator of transcription 3 (Stat3) has emerged as a critical regulator for tumor-associated inflammation. Activation of Stat3 negatively regulates the Th1-type immune response and promotes expansion of myeloid-derived suppressor cells (MDSCs) and regulatory T-cell functions in the tumor microenvironment. Mounting evidence suggests that Stat3 and related pathways may serve as a target for changing the tumor immunologic microenvironment to benefit cancer immunotherapies. Many recent studies support the use of certain tyrosine kinase inhibitors, through inhibition of Stat3, in decreasing immunosuppression in the tumor microenvironment. Other potential therapeutic avenues include the use of targeted delivery of Stat3 siRNA into immune cells. Here, we describe the role of Stat3 in regulating the immunologic properties of tumors as a background for Stat3-based therapeutic interventions. äSTAT3: A Target to Enhance Antitumor Immune Response (epmc).pdf DeepDyve Pubget Overpricing