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http://scihub22266oqcxt.onion/ C323503!323503!3458184     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Proc+Natl+Acad+Sci+U+S+A 1986 ; 83 (10): 3311-5 Nephropedia Template TP {{tp|p=3458184|t=1986. Membrane phospholipid asymmetry as a determinant of erythrocyte recognition by macrophages |pdf=|usr=}}{{3458184}} gab.com Text Membrane phospholipid asymmetry as a determinant of erythrocyte recognition by macrophages JO: Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=3458184 #FOAvip To assess the role of transbilayer phospholipid distribution in the recognition and phagocytosis of erythrocytes by macrophages, human erythrocytes with either a symmetric or asymmetric distribution of membrane phospholipids were prepared by hypotonic hemolysis and then incubated with cultures of human monocyte-derived macrophages. Erythrocytes with an abnormal, symmetric distribution were phagocytosed 4 times more readily than their counterparts with an asymmetric distribution or than normal, asymmetric intact erythrocytes. This enhanced phagocytosis correlated with two biophysical properties of the membrane: the spacing of phospholipids, as assessed by binding of the dye merocyanine 540, and the relative hydrophobicity, as measured by aqueous two-phase polymer partitioning. These results suggest a mechanism by which loss of membrane asymmetry is translated into recognition by macrophages and provide guidelines in loading erythrocytes that may be useful in manipulating the mode of delivery when erythrocytes are used as drug carriers in vivo.Images: Twit Text FOAVip Membrane phospholipid asymmetry as a determinant of erythrocyte recognition by macrophages ????Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=3458184 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=3458184 #FOAvip English Wikipedia <ref>{{Cite pmid|3458184}}</ref> Membrane phospholipid asymmetry as a determinant of erythrocyte recognition by macrophages #MMPMID3458184 McEvoy L; Williamson P; Schlegel RA Proc Natl Acad Sci U S A 1986[May]; 83 (10): 3311-5 PMID3458184show ga To assess the role of transbilayer phospholipid distribution in the recognition and phagocytosis of erythrocytes by macrophages, human erythrocytes with either a symmetric or asymmetric distribution of membrane phospholipids were prepared by hypotonic hemolysis and then incubated with cultures of human monocyte-derived macrophages. Erythrocytes with an abnormal, symmetric distribution were phagocytosed 4 times more readily than their counterparts with an asymmetric distribution or than normal, asymmetric intact erythrocytes. This enhanced phagocytosis correlated with two biophysical properties of the membrane: the spacing of phospholipids, as assessed by binding of the dye merocyanine 540, and the relative hydrophobicity, as measured by aqueous two-phase polymer partitioning. These results suggest a mechanism by which loss of membrane asymmetry is translated into recognition by macrophages and provide guidelines in loading erythrocytes that may be useful in manipulating the mode of delivery when erythrocytes are used as drug carriers in vivo.Images: äMembrane phospholipid asymmetry as a determinant of erythrocyte recogn(epmc).pdf DeepDyve Pubget Overpricing