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10.4049/jimmunol.1101225 http://scihub22266oqcxt.onion/10.4049/jimmunol.1101225 C3221925!3221925!22039302     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=22039302&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Immunol 2011 ; 187 (11): 6120-9 Nephropedia Template TP {{tp|p=22039302|t=2011. Adenosinergic regulation of the expansion and immunosuppressive activity of CD11b+Gr1+ cells |pdf=|usr=}}{{22039302}} gab.com Text Adenosinergic regulation of the expansion and immunosuppressive activity of CD11b+Gr1+ cells JO: J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=22039302 #FOAvip Extracellular adenosine and purine nucleotides are elevated in many pathological situations associated with the expansion of CD11b+Gr1+ myeloid-derived suppressor cells (MDSCs). Therefore, we tested whether adenosinergic pathways play a role in MDSC expansion and functions. We found that A2B adenosine receptors on hematopoietic cells play an important role in accumulation of intratumoral CD11b+Gr1high cells in a mouse Lewis lung carcinoma (LLC) model in vivo and demonstrated that these receptors promote preferential expansion of the granulocytic CD11b+Gr1high subset of MDSCs in vitro. Flow cytometry analysis of MDSCs generated from mouse hematopoietic progenitor cells revealed that the CD11b+Gr-1high subset had the highest levels of CD73 (ecto-5?-nucleotidase) expression (?MFI of 118.5±16.8), followed by CD11b+Gr-1int (?MFI of 57.9±6.8) and CD11b+Gr-1?/low (?MFI of 12.4±1.0). Even lower levels of CD73 expression were found on LLC tumor cells (?MFI of 3.2±0.2). The high levels of CD73 expression in granulocytic CD11b+Gr-1high cells correlated with high levels of ecto-5?-nucletidase enzymatic activity. We further demonstrated that the ability of granulocytic MDSCs to suppress CD3/CD28-induced T cell proliferation is significantly facilitated in the presence of the ecto-5?-nucletidase substrate 5?-AMP. We propose that generation of adenosine by CD73 expressed at high levels on granulocytic MDSCs may promote their expansion and facilitate their immunosuppressive activity. Twit Text FOAVip Adenosinergic regulation of the expansion and immunosuppressive activity of CD11b+Gr1+ cells ????J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=22039302 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=22039302 #FOAvip English Wikipedia <ref>{{Cite pmid|22039302}}</ref> Adenosinergic regulation of the expansion and immunosuppressive activity of CD11b+Gr1+ cells #MMPMID22039302 Ryzhov S; Novitskiy SV; Goldstein AE; Biktasova A; Blackburn MR; Biaggioni I; Dikov MM; Feoktistov I J Immunol 2011[Dec]; 187 (11): 6120-9 PMID22039302show ga Extracellular adenosine and purine nucleotides are elevated in many pathological situations associated with the expansion of CD11b+Gr1+ myeloid-derived suppressor cells (MDSCs). Therefore, we tested whether adenosinergic pathways play a role in MDSC expansion and functions. We found that A2B adenosine receptors on hematopoietic cells play an important role in accumulation of intratumoral CD11b+Gr1high cells in a mouse Lewis lung carcinoma (LLC) model in vivo and demonstrated that these receptors promote preferential expansion of the granulocytic CD11b+Gr1high subset of MDSCs in vitro. Flow cytometry analysis of MDSCs generated from mouse hematopoietic progenitor cells revealed that the CD11b+Gr-1high subset had the highest levels of CD73 (ecto-5?-nucleotidase) expression (?MFI of 118.5±16.8), followed by CD11b+Gr-1int (?MFI of 57.9±6.8) and CD11b+Gr-1?/low (?MFI of 12.4±1.0). Even lower levels of CD73 expression were found on LLC tumor cells (?MFI of 3.2±0.2). The high levels of CD73 expression in granulocytic CD11b+Gr-1high cells correlated with high levels of ecto-5?-nucletidase enzymatic activity. We further demonstrated that the ability of granulocytic MDSCs to suppress CD3/CD28-induced T cell proliferation is significantly facilitated in the presence of the ecto-5?-nucletidase substrate 5?-AMP. We propose that generation of adenosine by CD73 expressed at high levels on granulocytic MDSCs may promote their expansion and facilitate their immunosuppressive activity. äAdenosinergic regulation of the expansion and immunosuppressive activi(epmc).pdf DeepDyve Pubget Overpricing