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10.1007/s12011-011-9041-x http://scihub22266oqcxt.onion/10.1007/s12011-011-9041-x C3214234!3214234 !21484406     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\21484406 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Biol+Trace+Elem+Res 2011 ; 144 (1-3 ): 621-35 Nephropedia Template TP {{tp|p=21484406 |t=2011. Fibroblast response to lanthanoid metal ion stimulation: potential contribution to fibrotic tissue injury |pdf=|usr=}}{{21484406 }} gab.com Text Fibroblast response to lanthanoid metal ion stimulation: potential contribution to fibrotic tissue injury JO: Biol Trace Elem Res http://www.kidney.de/pget.php?&tw=1&pmid=21484406 #FOAvip The purpose of this study was to compare each of the 14 naturally occurring lanthanoid metal ions for ability to stimulate pro-fibrotic responses in human dermal fibroblasts. When fibroblasts were exposed to individual lanthanoids over the concentration range of 1-100 ?M, increased proliferation was observed with each of the agents as compared with control cells that were already proliferating rapidly in a growth factor-enriched culture medium. Dose-response differences were observed among the individual metal ions. Matrix metalloproteinase-1 (MMP-1) and tissue inhibitor of metalloproteinase-1 levels were also increased in response to lanthanoid exposure but type I procollagen production was not. A dose-response relationship between induction of proliferation and increased MMP-1 was observed. Non-lanthanoid transition metal ions (aluminum, copper, cobalt, iron, magnesium, manganese, nickel, and zinc) were examined in the same assays; there was little stimulation with any of these metals. When epidermal keratinocytes were examined in place of dermal fibroblasts, there was no growth stimulation with any of the lanthanoids. Several of the lanthanoid metals inhibited keratinocyte proliferation at higher concentrations (50-100 ?M). Twit Text FOAVip Fibroblast response to lanthanoid metal ion stimulation: potential contribution to fibrotic tissue injury ????Biol Trace Elem Res http://www.kidney.de/pget.php?&tw=1&pmid=21484406 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=21484406 #FOAvip English Wikipedia <ref>{{Cite pmid|21484406 }}</ref> Fibroblast response to lanthanoid metal ion stimulation: potential contribution to fibrotic tissue injury #MMPMID21484406 Jenkins W ; Perone P ; Walker K ; Bhagavathula N ; Aslam MN ; DaSilva M ; Dame MK ; Varani J Biol Trace Elem Res 2011[Dec]; 144 (1-3 ): 621-35 PMID21484406 show ga The purpose of this study was to compare each of the 14 naturally occurring lanthanoid metal ions for ability to stimulate pro-fibrotic responses in human dermal fibroblasts. When fibroblasts were exposed to individual lanthanoids over the concentration range of 1-100 ?M, increased proliferation was observed with each of the agents as compared with control cells that were already proliferating rapidly in a growth factor-enriched culture medium. Dose-response differences were observed among the individual metal ions. Matrix metalloproteinase-1 (MMP-1) and tissue inhibitor of metalloproteinase-1 levels were also increased in response to lanthanoid exposure but type I procollagen production was not. A dose-response relationship between induction of proliferation and increased MMP-1 was observed. Non-lanthanoid transition metal ions (aluminum, copper, cobalt, iron, magnesium, manganese, nickel, and zinc) were examined in the same assays; there was little stimulation with any of these metals. When epidermal keratinocytes were examined in place of dermal fibroblasts, there was no growth stimulation with any of the lanthanoids. Several of the lanthanoid metals inhibited keratinocyte proliferation at higher concentrations (50-100 ?M). |Apoptosis/drug effects [MESH] |Blotting, Western [MESH] |Cadherins/biosynthesis/metabolism [MESH] |Cell Proliferation/drug effects [MESH] |Cell Survival/drug effects [MESH] |Cells, Cultured [MESH] |Collagen Type I/biosynthesis [MESH] |Fibroblasts/*drug effects [MESH] |Fibrosis/chemically induced/pathology [MESH] |Humans [MESH] |Indicators and Reagents [MESH] |Keratinocytes/drug effects [MESH] |Lanthanoid Series Elements/*pharmacology [MESH] |Matrix Metalloproteinase 1/biosynthesis/genetics [MESH] |Matrix Metalloproteinase 2/biosynthesis/genetics [MESH] |Skin/cytology/pathology [MESH] |Stimulation, Chemical [MESH] |Tissue Inhibitor of Metalloproteinase-1/biosynthesis [MESH]Fibroblast response to lanthanoid metal ion stimulation: potential con(epmc).pdf DeepDyve Pubget Overpricing