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10.1128/JVI.05830-11 http://scihub22266oqcxt.onion/10.1128/JVI.05830-11 C3209325!3209325 !21917972     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=21917972 &cmd=llinks): Failed to open stream: HTTP request failed! 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Major histocompatibility complex class II expression and hemagglutinin subtype influence the infectivity of type A influenza virus for respiratory dendritic cells |pdf=|usr=}}{{21917972 }} gab.com Text Major histocompatibility complex class II expression and hemagglutinin subtype influence the infectivity of type A influenza virus for respiratory dendritic cells JO: J Virol http://www.kidney.de/pget.php?&tw=1&pmid=21917972 #FOAvip Dendritic cells (DC) play a key role in antiviral immunity, functioning both as innate effector cells in early phases of the immune response and subsequently as antigen-presenting cells that activate the adaptive immune response. In the murine respiratory tract, there are several respiratory dendritic cell (RDC) subsets, including CD103(+) DC, CD11b(hi) DC, monocyte/macrophage DC, and plasmacytoid DC. However, little is known about the interaction between these tissue-resident RDC and viruses that are encountered during natural infection in the respiratory tract. Here, we show both in vitro and in vivo that the susceptibility of murine RDC to infection with type A influenza virus varies with the level of MHC class II expression by RDC and with the virus strain. Both CD103(+) and CD11b(hi) RDC, which express the highest basal level of major histocompatibility complex (MHC) class II, are highly susceptible to infection by type A influenza virus. However, efficient infection is restricted to type A influenza virus strains of the H2N2 subtype. Furthermore, enhanced infectivity by viruses of the H2N2 subtype is linked to expression of the I-E MHC class II locus product. These results suggest a potential novel role for MHC class II molecules in influenza virus infection and pathogenesis in the respiratory tract. Twit Text FOAVip Major histocompatibility complex class II expression and hemagglutinin subtype influence the infectivity of type A influenza virus for respiratory dendritic cells ????J Virol http://www.kidney.de/pget.php?&tw=1&pmid=21917972 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=21917972 #FOAvip English Wikipedia <ref>{{Cite pmid|21917972 }}</ref> Major histocompatibility complex class II expression and hemagglutinin subtype influence the infectivity of type A influenza virus for respiratory dendritic cells #MMPMID21917972 Hargadon KM ; Zhou H ; Albrecht RA ; Dodd HA ; García-Sastre A ; Braciale TJ J Virol 2011[Nov]; 85 (22 ): 11955-63 PMID21917972 show ga Dendritic cells (DC) play a key role in antiviral immunity, functioning both as innate effector cells in early phases of the immune response and subsequently as antigen-presenting cells that activate the adaptive immune response. In the murine respiratory tract, there are several respiratory dendritic cell (RDC) subsets, including CD103(+) DC, CD11b(hi) DC, monocyte/macrophage DC, and plasmacytoid DC. However, little is known about the interaction between these tissue-resident RDC and viruses that are encountered during natural infection in the respiratory tract. Here, we show both in vitro and in vivo that the susceptibility of murine RDC to infection with type A influenza virus varies with the level of MHC class II expression by RDC and with the virus strain. Both CD103(+) and CD11b(hi) RDC, which express the highest basal level of major histocompatibility complex (MHC) class II, are highly susceptible to infection by type A influenza virus. However, efficient infection is restricted to type A influenza virus strains of the H2N2 subtype. Furthermore, enhanced infectivity by viruses of the H2N2 subtype is linked to expression of the I-E MHC class II locus product. These results suggest a potential novel role for MHC class II molecules in influenza virus infection and pathogenesis in the respiratory tract. |*Gene Expression [MESH] |Animals [MESH] |Dendritic Cells/*immunology/*virology [MESH] |Female [MESH] |Hemagglutinin Glycoproteins, Influenza Virus/classification/*metabolism [MESH] |Histocompatibility Antigens Class II/*biosynthesis/*immunology [MESH] |Influenza A virus/classification/*growth & development [MESH] |Mice [MESH]Major histocompatibility complex class II expression and hemagglutinin(epmc).pdf DeepDyve Pubget Overpricing