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10.1016/j.it.2011.05.003 http://scihub22266oqcxt.onion/10.1016/j.it.2011.05.003 C3164311!3164311!21697013     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Trends+Immunol 2011 ; 32 (8): 345-9 Nephropedia Template TP {{tp|p=21697013|t=2011. Emerging Tim-3 functions in anti-microbial and tumor immunity |pdf=|usr=}}{{21697013}} gab.com Text Emerging Tim-3 functions in anti-microbial and tumor immunity JO: Trends Immunol http://www.kidney.de/pget.php?&tw=1&pmid=21697013 #FOAvip T cell immunoglobulin-3 (Tim-3) was identified as a marker of differentiated IFN-?-producing CD4+ T helper type 1 and CD8+ T cytotoxic type 1 cells. The interaction of Tim-3 with its ligand, galectin-9 (Gal-9), induces cell death and in vivo blockade of this interaction results in exacerbated autoimmunity and abrogation of tolerance in experimental models, establishing Tim-3 as a negative regulatory molecule. Recent studies have uncovered additional mechanisms by which Tim-3 negatively regulates T cell responses, such as by promoting the development of CD8+ T cell exhaustion and inducing expansion of myeloid-derived suppressor cells (MDSC). In contrast to this inhibitory effect on T cells, Tim-3-Gal-9 interaction promotes macrophage clearance of intracellular pathogens. Here, we will focus on the emerging role for Tim-3 in tumor and anti-microbial immunity. Twit Text FOAVip Emerging Tim-3 functions in anti-microbial and tumor immunity ????Trends Immunol http://www.kidney.de/pget.php?&tw=1&pmid=21697013 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=21697013 #FOAvip English Wikipedia <ref>{{Cite pmid|21697013}}</ref> Emerging Tim-3 functions in anti-microbial and tumor immunity #MMPMID21697013 Sakuishi K; Jayaraman P; Behar SM; Anderson AC; Kuchroo VK Trends Immunol 2011[Aug]; 32 (8): 345-9 PMID21697013show ga T cell immunoglobulin-3 (Tim-3) was identified as a marker of differentiated IFN-?-producing CD4+ T helper type 1 and CD8+ T cytotoxic type 1 cells. The interaction of Tim-3 with its ligand, galectin-9 (Gal-9), induces cell death and in vivo blockade of this interaction results in exacerbated autoimmunity and abrogation of tolerance in experimental models, establishing Tim-3 as a negative regulatory molecule. Recent studies have uncovered additional mechanisms by which Tim-3 negatively regulates T cell responses, such as by promoting the development of CD8+ T cell exhaustion and inducing expansion of myeloid-derived suppressor cells (MDSC). In contrast to this inhibitory effect on T cells, Tim-3-Gal-9 interaction promotes macrophage clearance of intracellular pathogens. Here, we will focus on the emerging role for Tim-3 in tumor and anti-microbial immunity. äEmerging Tim-3 functions in anti-microbial and tumor immunity (epmc).pdf DeepDyve Pubget Overpricing