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10.1371/journal.pone.0022401 http://scihub22266oqcxt.onion/10.1371/journal.pone.0022401 C3138787!3138787!21789257     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       PLoS+One 2011 ; 6 (7): ä Nephropedia Template TP {{tp|p=21789257|t=2011. Large Scale Comparison of Innate Responses to Viral and Bacterial Pathogens in Mouse and Macaque |pdf=|usr=}}{{21789257}} gab.com Text Large Scale Comparison of Innate Responses to Viral and Bacterial Pathogens in Mouse and Macaque JO: PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=21789257 #FOAvip Viral and bacterial infections of the lower respiratory tract are major causes of morbidity and mortality worldwide. Alveolar macrophages line the alveolar spaces and are the first cells of the immune system to respond to invading pathogens. To determine the similarities and differences between the responses of mice and macaques to invading pathogens we profiled alveolar macrophages from these species following infection with two viral (PR8 and Fuj/02 influenza A) and two bacterial (Mycobacterium tuberculosis and Francisella tularensis Schu S4) pathogens. Cells were collected at 6 time points following each infection and expression profiles were compared across and between species. Our analyses identified a core set of genes, activated in both species and across all pathogens that were predominantly part of the interferon response pathway. In addition, we identified similarities across species in the way innate immune cells respond to lethal versus non-lethal pathogens. On the other hand we also found several species and pathogen specific response patterns. These results provide new insights into mechanisms by which the innate immune system responds to, and interacts with, invading pathogens. Twit Text FOAVip Large Scale Comparison of Innate Responses to Viral and Bacterial Pathogens in Mouse and Macaque ????PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=21789257 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=21789257 #FOAvip English Wikipedia <ref>{{Cite pmid|21789257}}</ref> Large Scale Comparison of Innate Responses to Viral and Bacterial Pathogens in Mouse and Macaque #MMPMID21789257 Zinman G; Brower-Sinning R; Emeche CH; Ernst J; Huang GTW; Mahony S; Myers AJ; O'Dee DM; Flynn JL; Nau GJ; Ross TM; Salter RD; Benos PV; Bar Joseph Z; Morel PA PLoS One 2011[]; 6 (7): ä PMID21789257show ga Viral and bacterial infections of the lower respiratory tract are major causes of morbidity and mortality worldwide. Alveolar macrophages line the alveolar spaces and are the first cells of the immune system to respond to invading pathogens. To determine the similarities and differences between the responses of mice and macaques to invading pathogens we profiled alveolar macrophages from these species following infection with two viral (PR8 and Fuj/02 influenza A) and two bacterial (Mycobacterium tuberculosis and Francisella tularensis Schu S4) pathogens. Cells were collected at 6 time points following each infection and expression profiles were compared across and between species. Our analyses identified a core set of genes, activated in both species and across all pathogens that were predominantly part of the interferon response pathway. In addition, we identified similarities across species in the way innate immune cells respond to lethal versus non-lethal pathogens. On the other hand we also found several species and pathogen specific response patterns. These results provide new insights into mechanisms by which the innate immune system responds to, and interacts with, invading pathogens. äLarge Scale Comparison of Innate Responses to Viral and Bacterial Path(epmc).pdf DeepDyve Pubget Overpricing