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10.1128/JVI.01817-10

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C3126269!3126269!21325425
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suck abstract from ncbi


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pmid21325425      J+Virol 2011 ; 85 (9): 4567-71
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  • Upregulation of Insulin-Like Growth Factor Binding Protein 3 in Astrocytes of Transgenic Mice That Express Borna Disease Virus Phosphoprotein?? #MMPMID21325425
  • Honda T; Fujino K; Okuzaki D; Ohtaki N; Matsumoto Y; Horie M; Daito T; Itoh M; Tomonaga K
  • J Virol 2011[May]; 85 (9): 4567-71 PMID21325425show ga
  • In a previous study, we demonstrated that transgenic mice that express Borna disease virus (BDV) phosphoprotein (P) in astrocytes show striking neurobehavioral abnormalities resembling those in BDV-infected animals. To understand the molecular disturbances induced by the expression of P in astrocytes, we performed microarray analysis with cultured astroglial cells transiently expressing P. We showed that expression of insulin-like growth factor binding protein 3 mRNA increases not only in P-expressing cultured cells but also in astrocytes from the cerebella of P transgenic mice (P-Tg). Furthermore, we demonstrated that insulin-like growth factor signaling is disturbed in the P-Tg cerebellum, a factor that might be involved in the increased vulnerability of Purkinje cell neurons in the brain.
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