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10.1016/j.intimp.2011.01.013 http://scihub22266oqcxt.onion/10.1016/j.intimp.2011.01.013 C3121950!3121950 !21281752     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\21281752 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Int+Immunopharmacol 2011 ; 11 (7 ): 794-801 Nephropedia Template TP {{tp|p=21281752 |t=2011. The role of myeloid receptors on murine plasmacytoid dendritic cells in induction of type I interferon |pdf=|usr=}}{{21281752 }} gab.com Text The role of myeloid receptors on murine plasmacytoid dendritic cells in induction of type I interferon JO: Int Immunopharmacol http://www.kidney.de/pget.php?&tw=1&pmid=21281752 #FOAvip This study tested the hypothesis that a set of predominantly myeloid restricted receptors (F4/80, CD36, Dectin-1, CD200 receptor and mannan binding lectins) and the broadly expressed CD200 played a role in a key function of plasmacytoid DC (pDC), virally induced type I interferon (IFN) production. The Dectin-1 ligands zymosan, glucan phosphate and the anti-Dectin-1 monoclonal antibody (mAb) 2A11 had no effect on influenza virus induced IFN?/? production by murine splenic pDC. However, mannan, a broad blocking reagent against mannose specific receptors, inhibited IFN?/? production by pDC in response to inactivated influenza virus. Moreover, viral glycoproteins (influenza virus haemagglutinin and HIV-1 gp120) stimulated IFN?/? production by splenocytes in a mannan-inhibitable manner, implicating the function of a lectin in glycoprotein induced IFN production. Lastly, the effect of CD200 on IFN induction was investigated. CD200 knock-out macrophages produced more IFN? than wild-type macrophages in response to polyI:C, a MyD88-independent stimulus, consistent with CD200's known inhibitory effect on myeloid cells. In contrast, blocking CD200 with an anti-CD200 mAb resulted in reduced IFN? production by pDC-containing splenocytes in response to CpG and influenza virus (MyD88-dependent stimuli). This suggests there could be a differential effect of CD200 on MyD88 dependent and independent IFN induction pathways in pDC and macrophages. This study supports the hypothesis that a mannan-inhibitable lectin and CD200 are involved in virally induced type I IFN induction. Twit Text FOAVip The role of myeloid receptors on murine plasmacytoid dendritic cells in induction of type I interferon ????Int Immunopharmacol http://www.kidney.de/pget.php?&tw=1&pmid=21281752 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=21281752 #FOAvip English Wikipedia <ref>{{Cite pmid|21281752 }}</ref> The role of myeloid receptors on murine plasmacytoid dendritic cells in induction of type I interferon #MMPMID21281752 Seeds RE ; Mukhopadhyay S ; Jones IM ; Gordon S ; Miller JL Int Immunopharmacol 2011[Jul]; 11 (7 ): 794-801 PMID21281752 show ga This study tested the hypothesis that a set of predominantly myeloid restricted receptors (F4/80, CD36, Dectin-1, CD200 receptor and mannan binding lectins) and the broadly expressed CD200 played a role in a key function of plasmacytoid DC (pDC), virally induced type I interferon (IFN) production. The Dectin-1 ligands zymosan, glucan phosphate and the anti-Dectin-1 monoclonal antibody (mAb) 2A11 had no effect on influenza virus induced IFN?/? production by murine splenic pDC. However, mannan, a broad blocking reagent against mannose specific receptors, inhibited IFN?/? production by pDC in response to inactivated influenza virus. Moreover, viral glycoproteins (influenza virus haemagglutinin and HIV-1 gp120) stimulated IFN?/? production by splenocytes in a mannan-inhibitable manner, implicating the function of a lectin in glycoprotein induced IFN production. Lastly, the effect of CD200 on IFN induction was investigated. CD200 knock-out macrophages produced more IFN? than wild-type macrophages in response to polyI:C, a MyD88-independent stimulus, consistent with CD200's known inhibitory effect on myeloid cells. In contrast, blocking CD200 with an anti-CD200 mAb resulted in reduced IFN? production by pDC-containing splenocytes in response to CpG and influenza virus (MyD88-dependent stimuli). This suggests there could be a differential effect of CD200 on MyD88 dependent and independent IFN induction pathways in pDC and macrophages. This study supports the hypothesis that a mannan-inhibitable lectin and CD200 are involved in virally induced type I IFN induction. |Animals [MESH] |Antibodies, Blocking/pharmacology [MESH] |Antigens, CD/genetics/immunology/*metabolism [MESH] |Antigens, Viral/immunology/metabolism [MESH] |Dendritic Cells/drug effects/immunology/*metabolism/pathology/virology [MESH] |Interferon Type I/metabolism [MESH] |Mannans/pharmacology [MESH] |Mice [MESH] |Mice, 129 Strain [MESH] |Mice, Inbred C57BL [MESH] |Mice, Knockout [MESH] |Myeloid Cells/immunology/*metabolism [MESH] |Myeloid Differentiation Factor 88/metabolism [MESH] |Orthomyxoviridae Infections/*immunology [MESH]The role of myeloid receptors on murine plasmacytoid dendritic cells i(epmc).pdf DeepDyve Pubget Overpricing