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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 J+Clin+Microbiol
2003 ; 41
(12
): 5577-81
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Borna disease virus RNA in immunocompromised patients in southwestern France
#MMPMID14662943
Cotto E
; Neau D
; Cransac-Neau M
; Auriacombe M
; Pellegrin JL
; Ragnaud JM
; Fillet AM
; Belnard M
; Fleury H
; Lafon ME
J Clin Microbiol
2003[Dec]; 41
(12
): 5577-81
PMID14662943
show ga
Borna disease virus (BDV) is a neurotropic RNA virus with a wide host range.
Human infections, although controversial, have been described in Europe, Asia,
and the United States. The present study investigated the existence of BDV
infections in immunocompromised human beings, namely, 82 human immunodeficiency
virus (HIV)-infected and 80 therapeutically immunosuppressed patients. BDV p40
RNAs were detected in peripheral white blood cells with reverse
transcription-nested PCR and hybridization in, respectively, 11 (13.41%) and 1
(1.25%) of the two groups of patients. BDV p24 RNAs were identified in only one
of those. BDV RNA was detected in the absence of any neuropsychiatrical illness,
suggesting that BDV infections may occur in asymptomatic carriers. The severity
and particularity of cellular immunosuppression could explain the significantly
increased detection of BDV RNA in HIV-infected patients.