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10.1016/j.immuni.2011.02.004 http://scihub22266oqcxt.onion/10.1016/j.immuni.2011.02.004 C3064726!3064726!21376641     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Immunity 2011 ; 34 (3): 385-95 Nephropedia Template TP {{tp|p=21376641|t=2011. Paired Immunoglobin Like Receptor-B regulates the suppressive function and fate of myeloid derived suppressor cells |pdf=|usr=}}{{21376641}} gab.com Text Paired Immunoglobin Like Receptor-B regulates the suppressive function and fate of myeloid derived suppressor cells JO: Immunity http://www.kidney.de/pget.php?&tw=1&pmid=21376641 #FOAvip Myeloid-derived suppressor cells (MDSCs) bear characteristics of precursors for both M1 and M2 macrophages. The molecular mechanism underlying the differentiation into M1 and M2 macrophages and the relationship of this differentiation to anti-tumor responses remains largely undefined. Herein we investigate the potential function of paired immunoglobulin-like receptor B (PIR-B), also knows as leukocyte immunoglobulin-like receptor subfamily B member 3 (LILRB3) in MDSC differentiation and its role in tumor-induced immunity. Our studies indicated that MDSCs genetically ablated for PIR-B (Lilrb3?/?) underwent a specific transition to M1-like cells when entering the periphery from bone marrow, resulting in decreased suppressive function, regulatory T cell activation activity, primary tumor growth, and lung metastases. Activation of toll-like receptor (TLR), signal transducers and activators of transcription 1 (STAT1), and nuclear factor-kappa B (NF-?B) signaling in Lilrb3?/? MDSC promoted the acquisition of M1 phenotype. Inhibition of the PIR-B signaling pathway promoted MDSC differentiation into M1 macrophages. Twit Text FOAVip Paired Immunoglobin Like Receptor-B regulates the suppressive function and fate of myeloid derived suppressor cells ????Immunity http://www.kidney.de/pget.php?&tw=1&pmid=21376641 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=21376641 #FOAvip English Wikipedia <ref>{{Cite pmid|21376641}}</ref> Paired Immunoglobin Like Receptor-B regulates the suppressive function and fate of myeloid derived suppressor cells #MMPMID21376641 Ma G; Pan PY; Eisenstein S; Divino CM; Chen SH Immunity 2011[Mar]; 34 (3): 385-95 PMID21376641show ga Myeloid-derived suppressor cells (MDSCs) bear characteristics of precursors for both M1 and M2 macrophages. The molecular mechanism underlying the differentiation into M1 and M2 macrophages and the relationship of this differentiation to anti-tumor responses remains largely undefined. Herein we investigate the potential function of paired immunoglobulin-like receptor B (PIR-B), also knows as leukocyte immunoglobulin-like receptor subfamily B member 3 (LILRB3) in MDSC differentiation and its role in tumor-induced immunity. Our studies indicated that MDSCs genetically ablated for PIR-B (Lilrb3?/?) underwent a specific transition to M1-like cells when entering the periphery from bone marrow, resulting in decreased suppressive function, regulatory T cell activation activity, primary tumor growth, and lung metastases. Activation of toll-like receptor (TLR), signal transducers and activators of transcription 1 (STAT1), and nuclear factor-kappa B (NF-?B) signaling in Lilrb3?/? MDSC promoted the acquisition of M1 phenotype. Inhibition of the PIR-B signaling pathway promoted MDSC differentiation into M1 macrophages. äPaired Immunoglobin Like Receptor-B regulates the suppressive function(epmc).pdf DeepDyve Pubget Overpricing