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Highly pathogenic or low pathogenic avian influenza virus subtype H7N1 infection
in chicken lungs: small differences in general acute responses
#MMPMID21314972
Rebel JM
; Peeters B
; Fijten H
; Post J
; Cornelissen J
; Vervelde L
Vet Res
2011[Jan]; 42
(1
): 10
PMID21314972
show ga
Avian influenza virus can be divided into two groups, highly pathogenic avian
influenza virus (HPAI) and low pathogenic avian influenza virus (LPAI) based on
their difference in virulence. To investigate if the difference in clinical
outcome between LPAI and HPAI in chickens is due to immunological host responses
in the lung within the first 24 hours post infection (hpi), chickens were
infected with LPAI or HPAI of subtype H7N1. Virus was found in the caudal and
cranial part of the lung. With LPAI, virus was localised around the
intrapulmonary bronchus and secondary bronchi. In sharp contrast, HPAI was
detected throughout the whole lung. However, based on viral RNA levels, no
quantitative difference was observed between LPAI and HPAI infected birds. In
infected areas of the lungs, an influx of CD8?+ cells as well as KUL01+
macrophages and dendritic cells (DC) occurred as fast as 8 hpi in both infected
groups. No major difference between LPAI and HPAI infected birds in the induction
of cytokines and interferons at mRNA level in lung tissue was found.In
conclusion, the differences in lethality for chickens infected with LPAI or HPAI
could be ascribed to difference in location of the virus. However similar amounts
of viral RNA, similar cytokine mRNA levels, and similar influxes of CD8?+ and
KUL01+ macrophages and DC were found between HPAI and LPAI in the lungs. A
cytokine storm at mRNA level as described for mammals was not observed in the
lungs of HPAI infected birds within 24 hpi.
|Animals
[MESH]
|Chickens
[MESH]
|Cytokines/*genetics/immunology/metabolism
[MESH]
|Dendritic Cells/*immunology/pathology
[MESH]
|Influenza A Virus, H7N1 Subtype/genetics/*pathogenicity
[MESH]
|Influenza in Birds/*immunology/pathology/virology
[MESH]
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