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10.1016/j.antiviral.2010.11.007 http://scihub22266oqcxt.onion/10.1016/j.antiviral.2010.11.007 C3018546!3018546 !21093489     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=21093489 &cmd=llinks): Failed to open stream: HTTP request failed! 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Single-dose intranasal administration with mDEF201 (adenovirus vectored mouse interferon-alpha) confers protection from mortality in a lethal SARS-CoV BALB/c mouse model |pdf=|usr=}}{{21093489 }} gab.com Text Single-dose intranasal administration with mDEF201 (adenovirus vectored mouse interferon-alpha) confers protection from mortality in a lethal SARS-CoV BALB/c mouse model JO: Antiviral Res http://www.kidney.de/pget.php?&tw=1&pmid=21093489 #FOAvip Interferons (IFNs) are a first line of defense against viral infection. Herein we describe the use of an adenovirus vectored mouse IFN alpha gene (mDEF201) as a prophylactic and treatment countermeasure in a SARS-CoV-infected BALB/c mouse model. Complete survival protection was observed in mice given a single dose of mDEF201 administered intranasally 1, 3, 5, 7, or 14 days prior to lethal SARS-CoV challenge (p<0.001), and body weights of these treated mice were unaffected by the challenge. In addition, low doses of mDEF201 protected lungs in a dose dependent manner as measured by a reduction in gross pathology. Intranasal treatment with mDEF201 ranging from 10(6) to 10(8)PFU significantly protected mice against a lethal SARS-CoV infection in a dose dependent manner up to 12h post infection (p<0.001). The data suggest that mDEF201 is a new class of antiviral agent further development as treatment for SARS-CoV infections. Twit Text FOAVip Single-dose intranasal administration with mDEF201 (adenovirus vectored mouse interferon-alpha) confers protection from mortality in a lethal SARS-CoV BALB/c mouse model ????Antiviral Res http://www.kidney.de/pget.php?&tw=1&pmid=21093489 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=21093489 #FOAvip English Wikipedia <ref>{{Cite pmid|21093489 }}</ref> Single-dose intranasal administration with mDEF201 (adenovirus vectored mouse interferon-alpha) confers protection from mortality in a lethal SARS-CoV BALB/c mouse model #MMPMID21093489 Kumaki Y ; Ennis J ; Rahbar R ; Turner JD ; Wandersee MK ; Smith AJ ; Bailey KW ; Vest ZG ; Madsen JR ; Li JK ; Barnard DL Antiviral Res 2011[Jan]; 89 (1 ): 75-82 PMID21093489 show ga Interferons (IFNs) are a first line of defense against viral infection. Herein we describe the use of an adenovirus vectored mouse IFN alpha gene (mDEF201) as a prophylactic and treatment countermeasure in a SARS-CoV-infected BALB/c mouse model. Complete survival protection was observed in mice given a single dose of mDEF201 administered intranasally 1, 3, 5, 7, or 14 days prior to lethal SARS-CoV challenge (p<0.001), and body weights of these treated mice were unaffected by the challenge. In addition, low doses of mDEF201 protected lungs in a dose dependent manner as measured by a reduction in gross pathology. Intranasal treatment with mDEF201 ranging from 10(6) to 10(8)PFU significantly protected mice against a lethal SARS-CoV infection in a dose dependent manner up to 12h post infection (p<0.001). The data suggest that mDEF201 is a new class of antiviral agent further development as treatment for SARS-CoV infections. |Adenoviridae/genetics [MESH] |Administration, Intranasal [MESH] |Animals [MESH] |Antiviral Agents/*administration & dosage/immunology [MESH] |Biological Products/*administration & dosage/genetics/immunology [MESH] |Body Weight [MESH] |Chlorocebus aethiops [MESH] |Disease Models, Animal [MESH] |Female [MESH] |Genetic Vectors [MESH] |Humans [MESH] |Interferon-alpha/*administration & dosage/genetics/immunology [MESH] |Mice [MESH] |Mice, Inbred BALB C [MESH] |Severe Acute Respiratory Syndrome/mortality/pathology/*prevention & control [MESH] |Severe acute respiratory syndrome-related coronavirus/*immunology [MESH] |Survival Analysis [MESH]Single-dose intranasal administration with mDEF201 (adenovirus vectore(epmc).pdf DeepDyve Pubget Overpricing