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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Am+J+Pathol
2010 ; 177
(5
): 2185-90
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
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English Wikipedia
Highly pathogenic avian influenza virus H7N7 isolated from a fatal human case
causes respiratory disease in cats but does not spread systemically
#MMPMID20847292
van Riel D
; Rimmelzwaan GF
; van Amerongen G
; Osterhaus AD
; Kuiken T
Am J Pathol
2010[Nov]; 177
(5
): 2185-90
PMID20847292
show ga
Highly pathogenic avian influenza viruses (HPAIV) of the H5 and H7 subtypes
primarily infect poultry but are occasionally transmitted to humans and other
mammalian species, often causing severe disease. Previously we have shown that
HPAIV H5N1 causes severe systemic disease in cats. In this study, we investigated
whether HPAIV H7N7 isolated from a fatal human case is also able to cause disease
in cats. Additionally, we compared the cell tropism of both viruses by
immunohistochemistry and virus histochemistry. Three domestic cats were
inoculated intratracheally with HPAIV H7N7. Virus excretion was restricted to the
pharynx. At necropsy, 7 days post inoculation, lesions were restricted to the
respiratory tract in all cats. Lesions consisted of diffuse alveolar damage and
colocalized with virus antigen expression in type II pneumocytes and nonciliated
bronchiolar cells. The attachment patterns of HPAIV H7N7 and H5N1 were similar:
both viruses attached to nonciliated bronchiolar epithelial cells, type II
pneumocytes, as well as alveolar macrophages. These data show for the first time
that a non-H5 HPAIV is able to infect and cause respiratory disease in cats. The
failure of HPAIV H7N7 to spread beyond the respiratory tract was not explained by
differences in cell tropism compared to HPAIV H5N1. These findings suggest that
HPAIV H5N1 possesses other characteristics that allow it to cause systemic
disease in both humans and cats.