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http://scihub22266oqcxt.onion/ C2958049!2958049!20626112     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Hepatol 2010 ; 53 (2): 298-306 Nephropedia Template TP {{tp|p=20626112|t=2010. Mechanisms of TNF?-induced cardiac dysfunction in cholestatic bile duct-ligated mice: Interaction between TNF? and endocannabinoids |pdf=|usr=}}{{20626112}} gab.com Text Mechanisms of TNF -induced cardiac dysfunction in cholestatic bile duct-ligated mice: Interaction between TNF and endocannabinoids JO: J Hepatol http://www.kidney.de/pget.php?&tw=1&pmid=20626112 #FOAvip Background & Aims: Chronic liver disease is associated with endotoxemia, oxidative stress, increased endocannabinoids and decreased cardiac responsiveness. Endocannabinoids activate the tumor necrosis factor-alpha (TNF?)?nuclear factor ?B (NF?B) pathway. However, how they interact with each other remains obscure. We therefore aimed to clarify the relationship between the TNF??NF?B pathway and endocannabinoids in the pathogenesis of cardiodepression of cholestatic bile duct ligated (BDL) mice. Methods: BDL mice with TNF? knockout (TNF??/?) and infusion of anti-TNF? antibody were used. Cardiac mRNA and protein expression of NF?Bp65, c-Jun-N-terminal kinases (JNK), p38 mitogen-activated protein kinase (p38MAPK), extracelullar-signal-regulated kinase (ERK), inducible nitric oxide synthase (iNOS), Copper/Zinc and Magnesium-superoxide dismutase (Cu/Zn- and Mn-SOD), cardiac anandamide, 2-arachidonoylglycerol (2-AG), nitric oxide (NOx) and glutathione, and plasma TNF? were measured. The effects of TNF?, cannabinoid receptor (CB1) antagonist AM251 and the endocannabinoid reuptake inhibitor UCM707, on the contractility of isolated cardiomyocytes, were assessed. Results: In BDL mice, cardiac mRNA and protein expression of NF?Bp65, p38MAPK, iNOS, NOx, anandamide, and plasma TNF? were increased, whereas glutathione, Cu/Zn-SOD, and Mn-SOD were decreased. Cardiac contractility was blunted in BDL mice. Anti-TNF? treatment in BDL mice decreased cardiac anandamide and NOx, reduced expression of NF?Bp65, p38MAPK, and iNOS, enhanced expression of Cu/Zn-SOD and Mn-SOD, increased reductive glutathione and restored cardiomyocyte contractility. TNF?-depressed contractility was worsened by UCM707, whereas AM251 improved contractility. Conclusions: Increased TNF?, acting via NF?B?iNOS and p38MAPK signaling pathways, plays an important role in the pathogenesis of cardiodepression in BDL mice. TNF? also suppressed contractility by increasing oxidative stress and endocannabinoid activity. Twit Text FOAVip Mechanisms of TNF -induced cardiac dysfunction in cholestatic bile duct-ligated mice: Interaction between TNF and endocannabinoids ????J Hepatol http://www.kidney.de/pget.php?&tw=1&pmid=20626112 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=20626112 #FOAvip English Wikipedia <ref>{{Cite pmid|20626112}}</ref> Mechanisms of TNF?-induced cardiac dysfunction in cholestatic bile duct-ligated mice: Interaction between TNF? and endocannabinoids #MMPMID20626112 Yang YY; Liu H; Nam SW; Kunos G; Lee SS J Hepatol 2010[Aug]; 53 (2): 298-306 PMID20626112show ga Background & Aims: Chronic liver disease is associated with endotoxemia, oxidative stress, increased endocannabinoids and decreased cardiac responsiveness. Endocannabinoids activate the tumor necrosis factor-alpha (TNF?)?nuclear factor ?B (NF?B) pathway. However, how they interact with each other remains obscure. We therefore aimed to clarify the relationship between the TNF??NF?B pathway and endocannabinoids in the pathogenesis of cardiodepression of cholestatic bile duct ligated (BDL) mice. Methods: BDL mice with TNF? knockout (TNF??/?) and infusion of anti-TNF? antibody were used. Cardiac mRNA and protein expression of NF?Bp65, c-Jun-N-terminal kinases (JNK), p38 mitogen-activated protein kinase (p38MAPK), extracelullar-signal-regulated kinase (ERK), inducible nitric oxide synthase (iNOS), Copper/Zinc and Magnesium-superoxide dismutase (Cu/Zn- and Mn-SOD), cardiac anandamide, 2-arachidonoylglycerol (2-AG), nitric oxide (NOx) and glutathione, and plasma TNF? were measured. The effects of TNF?, cannabinoid receptor (CB1) antagonist AM251 and the endocannabinoid reuptake inhibitor UCM707, on the contractility of isolated cardiomyocytes, were assessed. Results: In BDL mice, cardiac mRNA and protein expression of NF?Bp65, p38MAPK, iNOS, NOx, anandamide, and plasma TNF? were increased, whereas glutathione, Cu/Zn-SOD, and Mn-SOD were decreased. Cardiac contractility was blunted in BDL mice. Anti-TNF? treatment in BDL mice decreased cardiac anandamide and NOx, reduced expression of NF?Bp65, p38MAPK, and iNOS, enhanced expression of Cu/Zn-SOD and Mn-SOD, increased reductive glutathione and restored cardiomyocyte contractility. TNF?-depressed contractility was worsened by UCM707, whereas AM251 improved contractility. Conclusions: Increased TNF?, acting via NF?B?iNOS and p38MAPK signaling pathways, plays an important role in the pathogenesis of cardiodepression in BDL mice. TNF? also suppressed contractility by increasing oxidative stress and endocannabinoid activity. äMechanisms of TNF?-induced cardiac dysfunction in cholestatic bile duc(epmc).pdf DeepDyve Pubget Overpricing