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10.1038/ni.1861 http://scihub22266oqcxt.onion/10.1038/ni.1861 C2857582!2857582!20383149     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Immunol 2010 ; 11 (5): 404-10 Nephropedia Template TP {{tp|p=20383149|t=2010. Influenza virus activates inflammasomes through intracellular M2 channel |pdf=|usr=}}{{20383149}} gab.com Text Influenza virus activates inflammasomes through intracellular M2 channel JO: Nat Immunol http://www.kidney.de/pget.php?&tw=1&pmid=20383149 #FOAvip Influenza virus, a negative stranded RNA virus causing severe illness in humans and animals, stimulates the inflammasome through the NOD-like receptor (NLR), NLRP3. However, the mechanism by which influenza virus activates the NLRP3 inflammasome is unknown. Here, we show that the influenza virus M2 protein, a proton-selective ion channel important in viral pathogenesis, stimulates the NLRP3 inflammasome pathway. M2 channel activity was required for influenza activation of inflammasomes, and was sufficient to activate inflammasomes in primed macrophages and dendritic cells. M2-induced inflammasome activation required its localization to Golgi and was dependent on pH gradient. Our results reveal a mechanism by which influenza virus infection activates inflammasomes, and identifies the sensing of disturbances in intracellular ionic concentrations as a novel pathogen recognition pathway. Twit Text FOAVip Influenza virus activates inflammasomes through intracellular M2 channel ????Nat Immunol http://www.kidney.de/pget.php?&tw=1&pmid=20383149 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=20383149 #FOAvip English Wikipedia <ref>{{Cite pmid|20383149}}</ref> Influenza virus activates inflammasomes through intracellular M2 channel #MMPMID20383149 Ichinohe T; Pang IKs; Iwasaki A Nat Immunol 2010[May]; 11 (5): 404-10 PMID20383149show ga Influenza virus, a negative stranded RNA virus causing severe illness in humans and animals, stimulates the inflammasome through the NOD-like receptor (NLR), NLRP3. However, the mechanism by which influenza virus activates the NLRP3 inflammasome is unknown. Here, we show that the influenza virus M2 protein, a proton-selective ion channel important in viral pathogenesis, stimulates the NLRP3 inflammasome pathway. M2 channel activity was required for influenza activation of inflammasomes, and was sufficient to activate inflammasomes in primed macrophages and dendritic cells. M2-induced inflammasome activation required its localization to Golgi and was dependent on pH gradient. Our results reveal a mechanism by which influenza virus infection activates inflammasomes, and identifies the sensing of disturbances in intracellular ionic concentrations as a novel pathogen recognition pathway. äInfluenza virus activates inflammasomes through intracellular M2 chann(epmc).pdf DeepDyve Pubget Overpricing