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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Antimicrob+Agents+Chemother
1987 ; 31
(6
): 920-4
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Enhancement of bronchoalveolar cell recovery and stimulation of alveolar
macrophage chemiluminescence and resistance to influenza virus after treatment
with RU 41821 aerosol
#MMPMID3619424
Rudent A
; Michel F
; Labarre C
; Quero AM
; Zalisz R
; Smets P
Antimicrob Agents Chemother
1987[Jun]; 31
(6
): 920-4
PMID3619424
show ga
Aerosol treatment with RU 41821, a glycoprotein extract from Klebsiella
pneumoniae, was tested in mice for its effect on the kinetics of the induction of
bronchoalveolar cells (i.e., alveolar macrophages, monocytes, lymphocytes, and
polymorphonuclear leukocytes). RU 41821 led to an increase in the total number of
bronchoalveolar cells. The largest increase was observed for polymorphonuclear
leukocytes, and more moderate increases occurred in the numbers of alveolar
macrophages, monocytes, and lymphocytes. The alveolar macrophages recruited in
response to RU 41821 were activated, as indicated by luminol-dependent
chemiluminescence in response to stimulation by opsonized zymosan. The effects of
five RU 41821 aerosol treatments and those of a single treatment were further
examined in vivo by aerosol infection of mice inoculated with a mouse-pathogenic
influenza virus. The maximum protective effect was obtained after five once-a-day
treatments and was correlated with the largest increase in the total number of
bronchoalveolar cells.
|Aerosols
[MESH]
|Animals
[MESH]
|Antiviral Agents/*pharmacology
[MESH]
|Bacterial Proteins/*pharmacology
[MESH]
|Bronchi/*cytology/drug effects
[MESH]
|Female
[MESH]
|Influenza A virus/*drug effects
[MESH]
|Kinetics
[MESH]
|Luminescent Measurements
[MESH]
|Macrophages/*drug effects
[MESH]
|Mice
[MESH]
|Orthomyxoviridae Infections/microbiology/prevention & control
[MESH]