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10.1016/j.virol.2009.10.016 http://scihub22266oqcxt.onion/10.1016/j.virol.2009.10.016 C2789846!2789846 !19913271     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\19913271 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Virology 2010 ; 396 (2 ): 178-88 Nephropedia Template TP {{tp|p=19913271 |t=2010. Innate immune response to H3N2 and H1N1 influenza virus infection in a human lung organ culture model |pdf=|usr=}}{{19913271 }} gab.com Text Innate immune response to H3N2 and H1N1 influenza virus infection in a human lung organ culture model JO: Virology http://www.kidney.de/pget.php?&tw=1&pmid=19913271 #FOAvip We studied cytokine responses to influenza virus PR8 (H1N1) and Oklahoma/309/06 (OK/06, H3N2) in a novel human lung tissue model. Exposure of the model to influenza virus rapidly activated the mitogen-activated protein kinase signaling (MAPK) pathways ERK, p38 and JNK. In addition, RNase protection assay demonstrated the induction of several cytokine and chemokine mRNAs by virus. This finding was reflected at the translational level as IL-6, MCP-1, MIP-1 alpha/beta, IL-8 and IP-10 proteins were induced as determined by ELISA. Immunohistochemistry for IP-10 and MIP-1 alpha revealed that alveolar epithelial cells and macrophages were the source of these two cytokines. Taken together, both PR8 and OK/06 cause similar induction of cytokines in human lung, although OK/06 is less effective at inducing the chemokines MCP-1 and IL-8. This human organ culture model should thus provide a relevant platform to study the biological responses of human lung to influenza virus infection. Twit Text FOAVip Innate immune response to H3N2 and H1N1 influenza virus infection in a human lung organ culture model ????Virology http://www.kidney.de/pget.php?&tw=1&pmid=19913271 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=19913271 #FOAvip English Wikipedia <ref>{{Cite pmid|19913271 }}</ref> Innate immune response to H3N2 and H1N1 influenza virus infection in a human lung organ culture model #MMPMID19913271 Wu W ; Booth JL ; Duggan ES ; Wu S ; Patel KB ; Coggeshall KM ; Metcalf JP Virology 2010[Jan]; 396 (2 ): 178-88 PMID19913271 show ga We studied cytokine responses to influenza virus PR8 (H1N1) and Oklahoma/309/06 (OK/06, H3N2) in a novel human lung tissue model. Exposure of the model to influenza virus rapidly activated the mitogen-activated protein kinase signaling (MAPK) pathways ERK, p38 and JNK. In addition, RNase protection assay demonstrated the induction of several cytokine and chemokine mRNAs by virus. This finding was reflected at the translational level as IL-6, MCP-1, MIP-1 alpha/beta, IL-8 and IP-10 proteins were induced as determined by ELISA. Immunohistochemistry for IP-10 and MIP-1 alpha revealed that alveolar epithelial cells and macrophages were the source of these two cytokines. Taken together, both PR8 and OK/06 cause similar induction of cytokines in human lung, although OK/06 is less effective at inducing the chemokines MCP-1 and IL-8. This human organ culture model should thus provide a relevant platform to study the biological responses of human lung to influenza virus infection. |Chemokines/biosynthesis [MESH] |Cytokines/biosynthesis [MESH] |Enzyme Induction/immunology [MESH] |Humans [MESH] |Immunity, Innate/*immunology [MESH] |Influenza A Virus, H1N1 Subtype/*immunology/physiology [MESH] |Influenza A Virus, H3N2 Subtype/*immunology/physiology [MESH] |Influenza, Human/*immunology/virology [MESH] |Lung/immunology/*virology [MESH] |Mitogen-Activated Protein Kinase Kinases/biosynthesis [MESH] |Organ Culture Techniques [MESH]Innate immune response to H3N2 and H1N1 influenza virus infection in a(epmc).pdf DeepDyve Pubget Overpricing