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10.1016/j.immuni.2009.02.006 http://scihub22266oqcxt.onion/10.1016/j.immuni.2009.02.006 C2765464!2765464!19362023     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Immunity 2009 ; 30 (4): 566-75 Nephropedia Template TP {{tp|p=19362023|t=2009. NLRP3 (NALP3/CIAS1/Cryopyrin) mediates key innate and healing responses to influenza A virus via the regulation of caspase-1 |pdf=|usr=}}{{19362023}} gab.com Text NLRP3 (NALP3/CIAS1/Cryopyrin) mediates key innate and healing responses to influenza A virus via the regulation of caspase-1 JO: Immunity http://www.kidney.de/pget.php?&tw=1&pmid=19362023 #FOAvip Virus-induced IL-1? and IL-18 production in macrophages is mediated via a caspase-1 pathway. Multiple microbial components, including viral RNA, are thought to trigger assembly of the cryopyrin inflammasome and consequent caspase-1 activation. Here we demonstrate that cryopyrin?/? and caspase-1?/? mice are more susceptible than wildtype controls following infection with a pathogenic influenza A virus. This profile of enhanced morbidity correlates with decreased neutrophil and monocyte recruitment and reduced cytokine and chemokine production. Despite the effect on innate immunity, cryopyrin-deficiency was not associated with any obvious defect in virus control or on the later emergence of the adaptive response. Early epithelial necrosis was, however, more severe in the infected mutants, with extensive collagen deposition leading to later respiratory compromise. These findings reveal a novel function of the cryopyrin inflammasome in healing responses. Cryopyrin and caspase-1 are clearly central to both innate immunity and to moderating lung pathology in influenza pneumonia. Twit Text FOAVip NLRP3 (NALP3/CIAS1/Cryopyrin) mediates key innate and healing responses to influenza A virus via the regulation of caspase-1 ????Immunity http://www.kidney.de/pget.php?&tw=1&pmid=19362023 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=19362023 #FOAvip English Wikipedia <ref>{{Cite pmid|19362023}}</ref> NLRP3 (NALP3/CIAS1/Cryopyrin) mediates key innate and healing responses to influenza A virus via the regulation of caspase-1 #MMPMID19362023 Thomas PG; Dash P; Aldridge JR; Ellebedy AH; Reynolds C; Funk AJ; Martin WJ; Lamkanfi M; Webby RJ; Boyd KL; Doherty PC; Kanneganti TD Immunity 2009[Apr]; 30 (4): 566-75 PMID19362023show ga Virus-induced IL-1? and IL-18 production in macrophages is mediated via a caspase-1 pathway. Multiple microbial components, including viral RNA, are thought to trigger assembly of the cryopyrin inflammasome and consequent caspase-1 activation. Here we demonstrate that cryopyrin?/? and caspase-1?/? mice are more susceptible than wildtype controls following infection with a pathogenic influenza A virus. This profile of enhanced morbidity correlates with decreased neutrophil and monocyte recruitment and reduced cytokine and chemokine production. Despite the effect on innate immunity, cryopyrin-deficiency was not associated with any obvious defect in virus control or on the later emergence of the adaptive response. Early epithelial necrosis was, however, more severe in the infected mutants, with extensive collagen deposition leading to later respiratory compromise. These findings reveal a novel function of the cryopyrin inflammasome in healing responses. Cryopyrin and caspase-1 are clearly central to both innate immunity and to moderating lung pathology in influenza pneumonia. äNLRP3 (NALP3/CIAS1/Cryopyrin) mediates key innate and healing response(epmc).pdf DeepDyve Pubget Overpricing