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10.1111/j.1462-5822.2008.01192.x http://scihub22266oqcxt.onion/10.1111/j.1462-5822.2008.01192.x C2758559!2758559!18616693     free     free     free       Cell+Microbiol 2008 ; 10 (11): 2151-8 Nephropedia Template TP {{tp|p=18616693|t=2008. Intracellular microbes and haemophagocytosis |pdf=|usr=}}{{18616693}} gab.com Text Intracellular microbes and haemophagocytosis JO: Cell Microbiol http://www.kidney.de/pget.php?&tw=1&pmid=18616693 #FOAvip Haemophagocytosis (hemophagocytosis) is the phenomenon of activated macrophage consumption of red and white blood cells, including professional phagocytes and lymphocytes. It can occur in patients with severe cases of intracellular microbial infection, including avian influenza, leishmaniasis, tuberculosis and typhoid fever. While well-known to physicians since at least the mid-1800s, haemophagocytosis has been little studied due to a paucity of tractable animal and cell culture models. Recently, haemophagocytosis has been described in a mouse model of typhoid fever, and it was noted that the infectious agent, Salmonella enterica, resides within haemophagocytic macrophages in mice. In addition, a cell culture model for haemophagocytosis revealed that S. enterica preferentially replicate in haemophagocytic macrophages. This review describes how, at the molecular and cellular levels, S. enterica may promote and take advantage of haemophagocytosis to establish long-term systemic infections in mammals. The role, relevance and possible molecular mechanisms of haemophagocytosis are discussed within the context of other microbial infections and of genetic deficiencies in which haemophagocytosis occurs and is associated with morbidity. Twit Text FOAVip Intracellular microbes and haemophagocytosis ????Cell Microbiol http://www.kidney.de/pget.php?&tw=1&pmid=18616693 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=18616693 #FOAvip English Wikipedia <ref>{{Cite pmid|18616693}}</ref> Intracellular microbes and haemophagocytosis #MMPMID18616693 Silva-Herzog E; Detweiler CS Cell Microbiol 2008[Nov]; 10 (11): 2151-8 PMID18616693show ga Haemophagocytosis (hemophagocytosis) is the phenomenon of activated macrophage consumption of red and white blood cells, including professional phagocytes and lymphocytes. It can occur in patients with severe cases of intracellular microbial infection, including avian influenza, leishmaniasis, tuberculosis and typhoid fever. While well-known to physicians since at least the mid-1800s, haemophagocytosis has been little studied due to a paucity of tractable animal and cell culture models. Recently, haemophagocytosis has been described in a mouse model of typhoid fever, and it was noted that the infectious agent, Salmonella enterica, resides within haemophagocytic macrophages in mice. In addition, a cell culture model for haemophagocytosis revealed that S. enterica preferentially replicate in haemophagocytic macrophages. This review describes how, at the molecular and cellular levels, S. enterica may promote and take advantage of haemophagocytosis to establish long-term systemic infections in mammals. The role, relevance and possible molecular mechanisms of haemophagocytosis are discussed within the context of other microbial infections and of genetic deficiencies in which haemophagocytosis occurs and is associated with morbidity. äIntracellular microbes and haemophagocytosis (epmc).pdf DeepDyve Pubget Overpricing