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10.1080/14653240802317647 http://scihub22266oqcxt.onion/10.1080/14653240802317647 C2757571!2757571!18836919     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cytotherapy 2008 ; 10 (6): 642-9 Nephropedia Template TP {{tp|p=18836919|t=2008. Whole lymphoma B cells allow efficient cross-presentation of antigens by dendritic cells |pdf=|usr=}}{{18836919}} gab.com Text Whole lymphoma B cells allow efficient cross-presentation of antigens by dendritic cells JO: Cytotherapy http://www.kidney.de/pget.php?&tw=1&pmid=18836919 #FOAvip Background: In order to compensate the paucity of defined tumor antigens in non-Hodgkin lymphomas, a promising approach might be the use of whole tumor cells as source of tumor antigens to pulse antigen-presenting cells. However, it is not presently known how the tumor cells should be delivered to antigen presenting cells to optimize the cross-presentation of tumor antigens to anti-tumor CD8 T cells. Here we aimed at comparing CD20-opsonized, apoptotic, and necrotic human tumor cells for their capacity to induce endocytosis and cross-presentation of tumor-associated antigens by dendritic cells or macrophages. Methods: Endocytosis of human tumor-derived material by macrophages or dendritic cells was monitored by flow cytometry. We used the previously described influenza model and studied cross-presentation of viral antigens as cellular surrogate tumor-associated antigens by antigen-presenting cells after endocytosis of lymphoma B cells treated by inactivated influenza virus. Results: Optimal endocytosis was obtained when tumor cells were opsonized by an anti-CD20 antibody, and as expected, macrophages were more phagocytic than dendritic cells. However, antigens from opsonized, apoptotic, and live cells but not from necrotic lymphoma cells were efficiently cross-presented by dendritic cells, but not by macrophages. Discussion: We developed a new model with human primary lymphoma cells to study the cross-presentation of tumor-associated antigens by APCs. The results we obtained support the use of whole lymphoma cells from patient to pulse dendritic cells to induce antitumor immune response. Twit Text FOAVip Whole lymphoma B cells allow efficient cross-presentation of antigens by dendritic cells ????Cytotherapy http://www.kidney.de/pget.php?&tw=1&pmid=18836919 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=18836919 #FOAvip English Wikipedia <ref>{{Cite pmid|18836919}}</ref> Whole lymphoma B cells allow efficient cross-presentation of antigens by dendritic cells #MMPMID18836919 Manches O; Lui G; Molens JP; Sotto JJ; Chaperot L; Plumas J Cytotherapy 2008[]; 10 (6): 642-9 PMID18836919show ga Background: In order to compensate the paucity of defined tumor antigens in non-Hodgkin lymphomas, a promising approach might be the use of whole tumor cells as source of tumor antigens to pulse antigen-presenting cells. However, it is not presently known how the tumor cells should be delivered to antigen presenting cells to optimize the cross-presentation of tumor antigens to anti-tumor CD8 T cells. Here we aimed at comparing CD20-opsonized, apoptotic, and necrotic human tumor cells for their capacity to induce endocytosis and cross-presentation of tumor-associated antigens by dendritic cells or macrophages. Methods: Endocytosis of human tumor-derived material by macrophages or dendritic cells was monitored by flow cytometry. We used the previously described influenza model and studied cross-presentation of viral antigens as cellular surrogate tumor-associated antigens by antigen-presenting cells after endocytosis of lymphoma B cells treated by inactivated influenza virus. Results: Optimal endocytosis was obtained when tumor cells were opsonized by an anti-CD20 antibody, and as expected, macrophages were more phagocytic than dendritic cells. However, antigens from opsonized, apoptotic, and live cells but not from necrotic lymphoma cells were efficiently cross-presented by dendritic cells, but not by macrophages. Discussion: We developed a new model with human primary lymphoma cells to study the cross-presentation of tumor-associated antigens by APCs. The results we obtained support the use of whole lymphoma cells from patient to pulse dendritic cells to induce antitumor immune response. äWhole lymphoma B cells allow efficient cross-presentation of antigens (epmc).pdf DeepDyve Pubget Overpricing