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10.2353/ajpath.2009.090339 http://scihub22266oqcxt.onion/10.2353/ajpath.2009.090339 C2731136!2731136!19700749     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Am+J+Pathol 2009 ; 175 (3): 1178-86 Nephropedia Template TP {{tp|p=19700749|t=2009. Spread of Infection and Lymphocyte Depletion in Mice Depends on Polymerase of Influenza Virus |pdf=|usr=}}{{19700749}} gab.com Text Spread of Infection and Lymphocyte Depletion in Mice Depends on Polymerase of Influenza Virus JO: Am J Pathol http://www.kidney.de/pget.php?&tw=1&pmid=19700749 #FOAvip SC35M is a mouse-adapted variant of the highly pathogenic avian influenza virus SC35. We have previously shown that interspecies adaptation is mediated by mutations in the viral polymerase and that it is paralleled by the acquisition of high pathogenicity for mice. In the present study, we have compared virus spread and organ tropism of SC35 and SC35M in mice. We show that SC35 virus causes mild bronchiolitis in these animals, whereas infection with the mouse-adapted SC35M virus leads to severe hemorrhagic pneumonia with dissemination to other organs, including the brain. In SC35M-infected animals, viral RNA and viral antigen were detected in monocytes and macrophages, and SC35M, unlike SC35, replicated in lymphocyte and macrophage cultures in vitro. SC35M did not induce an adequate cytokine response but, unlike SC35, caused severe lymphopenia in mice. These observations suggest that the high efficiency of the SC35M polymerase is responsible for infection and depletion of lymphocytes and other white blood cells, which results in immune suppression and systemic virus spread. Twit Text FOAVip Spread of Infection and Lymphocyte Depletion in Mice Depends on Polymerase of Influenza Virus ????Am J Pathol http://www.kidney.de/pget.php?&tw=1&pmid=19700749 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=19700749 #FOAvip English Wikipedia <ref>{{Cite pmid|19700749}}</ref> Spread of Infection and Lymphocyte Depletion in Mice Depends on Polymerase of Influenza Virus #MMPMID19700749 Gabriel G; Klingel K; Planz O; Bier K; Herwig A; Sauter M; Klenk HD Am J Pathol 2009[Sep]; 175 (3): 1178-86 PMID19700749show ga SC35M is a mouse-adapted variant of the highly pathogenic avian influenza virus SC35. We have previously shown that interspecies adaptation is mediated by mutations in the viral polymerase and that it is paralleled by the acquisition of high pathogenicity for mice. In the present study, we have compared virus spread and organ tropism of SC35 and SC35M in mice. We show that SC35 virus causes mild bronchiolitis in these animals, whereas infection with the mouse-adapted SC35M virus leads to severe hemorrhagic pneumonia with dissemination to other organs, including the brain. In SC35M-infected animals, viral RNA and viral antigen were detected in monocytes and macrophages, and SC35M, unlike SC35, replicated in lymphocyte and macrophage cultures in vitro. SC35M did not induce an adequate cytokine response but, unlike SC35, caused severe lymphopenia in mice. These observations suggest that the high efficiency of the SC35M polymerase is responsible for infection and depletion of lymphocytes and other white blood cells, which results in immune suppression and systemic virus spread. äSpread of Infection and Lymphocyte Depletion in Mice Depends on Polyme(epmc).pdf DeepDyve Pubget Overpricing