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10.1074/jbc.M109.004424 http://scihub22266oqcxt.onion/10.1074/jbc.M109.004424 C2707206!2707206!19433582     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Biol+Chem 2009 ; 284 (28): 19077-89 Nephropedia Template TP {{tp|p=19433582|t=2009. Magnesium Deficiency Causes Loss of Response to Intermittent Hypoxia in Paraganglion Cells* |pdf=|usr=}}{{19433582}} gab.com Text Magnesium Deficiency Causes Loss of Response to Intermittent Hypoxia in Paraganglion Cells* JO: J Biol Chem http://www.kidney.de/pget.php?&tw=1&pmid=19433582 #FOAvip Magnesium deficiency is suggested to contribute to many age-related diseases. Hypoxia-inducible factor 1? (HIF-1?) is known to be a master regulator of hypoxic response. Here we show that hypomagnesemia suppresses reactive oxygen species (ROS)-induced HIF-1? activity in paraganglion cells of the adrenal medulla and carotid body. In PC12 cells cultured in the low magnesium medium and treated with cobalt chloride (CoCl2) or exposed to intermittent hypoxia, ROS-mediated HIF-1? activity was suppressed. This suppression was due to up-regulation of inhibitory PAS (Per/Arnt/Sim) domain protein (IPAS) that was caused by NF-?B activation, which resulted from ROS and calcium influx mainly through the T-type calcium channels. Induction of tyrosine hydroxylase, a target of HIF-1, by CoCl2 injection was suppressed in the adrenal medulla of magnesium-deficient mice because of up-regulation of IPAS. Also in the carotid body of magnesium-deficient mice, CoCl2 and chronic intermittent hypoxia failed to enhance the tyrosine hydroxylase expression. These results demonstrate that serum magnesium levels are a key determinant for ROS-induced hypoxic responses. Twit Text FOAVip Magnesium Deficiency Causes Loss of Response to Intermittent Hypoxia in Paraganglion Cells* ????J Biol Chem http://www.kidney.de/pget.php?&tw=1&pmid=19433582 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=19433582 #FOAvip English Wikipedia <ref>{{Cite pmid|19433582}}</ref> Magnesium Deficiency Causes Loss of Response to Intermittent Hypoxia in Paraganglion Cells* #MMPMID19433582 Torii S; Kobayashi K; Takahashi M; Katahira K; Goryo K; Matsushita N; Yasumoto Ki; Fujii-Kuriyama Y; Sogawa K J Biol Chem 2009[Jul]; 284 (28): 19077-89 PMID19433582show ga Magnesium deficiency is suggested to contribute to many age-related diseases. Hypoxia-inducible factor 1? (HIF-1?) is known to be a master regulator of hypoxic response. Here we show that hypomagnesemia suppresses reactive oxygen species (ROS)-induced HIF-1? activity in paraganglion cells of the adrenal medulla and carotid body. In PC12 cells cultured in the low magnesium medium and treated with cobalt chloride (CoCl2) or exposed to intermittent hypoxia, ROS-mediated HIF-1? activity was suppressed. This suppression was due to up-regulation of inhibitory PAS (Per/Arnt/Sim) domain protein (IPAS) that was caused by NF-?B activation, which resulted from ROS and calcium influx mainly through the T-type calcium channels. Induction of tyrosine hydroxylase, a target of HIF-1, by CoCl2 injection was suppressed in the adrenal medulla of magnesium-deficient mice because of up-regulation of IPAS. Also in the carotid body of magnesium-deficient mice, CoCl2 and chronic intermittent hypoxia failed to enhance the tyrosine hydroxylase expression. These results demonstrate that serum magnesium levels are a key determinant for ROS-induced hypoxic responses. äMagnesium Deficiency Causes Loss of Response to Intermittent Hypoxia i(epmc).pdf DeepDyve Pubget Overpricing