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10.1097/TP.0b013e318186fccd http://scihub22266oqcxt.onion/10.1097/TP.0b013e318186fccd C2668611!2668611!18946352     free     free     free Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Transplantation 2008 ; 86 (8): 1125-34 Nephropedia Template TP {{tp|p=18946352|t=2008. Human Inhibitory Receptor ILT2 Amplifies CD11b+Gr1+ Myeloid-Derived Suppressor Cells that Promote Long-Term Survival of Allografts |pdf=|usr=}}{{18946352}} gab.com Text Human Inhibitory Receptor ILT2 Amplifies CD11b+Gr1+ Myeloid-Derived Suppressor Cells that Promote Long-Term Survival of Allografts JO: Transplantation http://www.kidney.de/pget.php?&tw=1&pmid=18946352 #FOAvip Background: The expression of HLA-G during allogeneic recognition is associated with better graft acceptance. The inhibitory receptor ILT2 is expressed on activated T cells and serves to shut down T cell activation, culminating in T cell death or induction of anergy. One of the potential mechanisms in the immunosuppressive accomplishment of HLA-G-ILT2 interactions involves the expansion of myeloid-derived suppressor cells (MDSCs). The potential of MDSCs in transplantation has not yet been exploited. Methods: (1) Detailed phenotypic characteristics, immunosuppressive potential of MDSCs expanded via inhibitory receptor ILT2 and its ligands, and allogeneic transplant-activated MDSCs were obtained in mice. (2) Oligo- and Real-time pathway-specific PCR Arrays were performed to characterize ILT2-specific MDSCs. (3) Skin allograft survival after adoptive transfer of MDSCs was studied. Results: Engagement of ILT2 receptors, especially by HLA-G, expanded the population of MDSCs with enhanced suppressive activity. Adoptive transfer of MDSCs generated via ILT2 receptor and its ligands prolonged graft survival in recipients of allogeneic skin transplant. We have proposed pathways for enhancement of immunosuppressive activities and expansion of MDSCs via ILT2 and HLA-G. Conclusions: Our results suggest that induction of MDSCs using ILT2 inhibitory receptor/HLA-G ligand may be an attractive strategy for preventing rejection of highly immunogenic organs/tissues in clinical transplantation. Twit Text FOAVip Human Inhibitory Receptor ILT2 Amplifies CD11b+Gr1+ Myeloid-Derived Suppressor Cells that Promote Long-Term Survival of Allografts ????Transplantation http://www.kidney.de/pget.php?&tw=1&pmid=18946352 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=18946352 #FOAvip English Wikipedia <ref>{{Cite pmid|18946352}}</ref> Human Inhibitory Receptor ILT2 Amplifies CD11b+Gr1+ Myeloid-Derived Suppressor Cells that Promote Long-Term Survival of Allografts #MMPMID18946352 Zhang W; Liang S; Wu J; Horuzsko A Transplantation 2008[Oct]; 86 (8): 1125-34 PMID18946352show ga Background: The expression of HLA-G during allogeneic recognition is associated with better graft acceptance. The inhibitory receptor ILT2 is expressed on activated T cells and serves to shut down T cell activation, culminating in T cell death or induction of anergy. One of the potential mechanisms in the immunosuppressive accomplishment of HLA-G-ILT2 interactions involves the expansion of myeloid-derived suppressor cells (MDSCs). The potential of MDSCs in transplantation has not yet been exploited. Methods: (1) Detailed phenotypic characteristics, immunosuppressive potential of MDSCs expanded via inhibitory receptor ILT2 and its ligands, and allogeneic transplant-activated MDSCs were obtained in mice. (2) Oligo- and Real-time pathway-specific PCR Arrays were performed to characterize ILT2-specific MDSCs. (3) Skin allograft survival after adoptive transfer of MDSCs was studied. Results: Engagement of ILT2 receptors, especially by HLA-G, expanded the population of MDSCs with enhanced suppressive activity. Adoptive transfer of MDSCs generated via ILT2 receptor and its ligands prolonged graft survival in recipients of allogeneic skin transplant. We have proposed pathways for enhancement of immunosuppressive activities and expansion of MDSCs via ILT2 and HLA-G. Conclusions: Our results suggest that induction of MDSCs using ILT2 inhibitory receptor/HLA-G ligand may be an attractive strategy for preventing rejection of highly immunogenic organs/tissues in clinical transplantation. äHuman Inhibitory Receptor ILT2 Amplifies CD11b+Gr1+ Myeloid-Derived Su(epmc).pdf DeepDyve Pubget Overpricing