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10.1016/j.vph.2008.11.001 http://scihub22266oqcxt.onion/10.1016/j.vph.2008.11.001 C2667157!2667157 !19084078     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=19084078 &cmd=llinks): Failed to open stream: HTTP request failed! 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Caffeine inhibits InsP3 responses and capacitative calcium entry in canine pulmonary arterial smooth muscle cells |pdf=|usr=}}{{19084078 }} gab.com Text Caffeine inhibits InsP3 responses and capacitative calcium entry in canine pulmonary arterial smooth muscle cells JO: Vascul Pharmacol http://www.kidney.de/pget.php?&tw=1&pmid=19084078 #FOAvip Caffeine is a well described and characterized ryanodine receptor (RyR) activator. Previous evidence from independent research studies also indicate caffeine inhibits InsP3 receptor functionality, which is important to activation of capacitative Ca2+ entry (CCE) in some cell types. In addition, RyR activation elicits excitatory-coupled Ca2+ entry (ECCE) in skeletal muscle myotubes. Recent studies by our group show that canine pulmonary arterial smooth muscle cells (PASMCs) have functional InsP3 receptors as well as RyRs, and that CCE is dependent on InsP3 receptor activity. The potential for caffeine to activate ECCE as well as inhibit InsP3 receptor function and CCE was examined using fura-2 fluorescent imaging in canine PASMCs. The data show caffeine causes transient as well as sustained cytosolic Ca2+ increases, though this is not due to CCE or ECCE activity as evidenced by a lack of an increase in Mn2+ quench of fura-2. The experiments also show caffeine reversibly inhibits 5-HT elicited-InsP3 mediated Ca2+ responses with an IC50 of 6.87x10(-4) M and 10 mM caffeine fully inhibits CCE. These studies provide the first evidence that caffeine is an inhibitor of InsP3 generated Ca2+ signals and CCE in PASMCs. Twit Text FOAVip Caffeine inhibits InsP3 responses and capacitative calcium entry in canine pulmonary arterial smooth muscle cells ????Vascul Pharmacol http://www.kidney.de/pget.php?&tw=1&pmid=19084078 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=19084078 #FOAvip English Wikipedia <ref>{{Cite pmid|19084078 }}</ref> Caffeine inhibits InsP3 responses and capacitative calcium entry in canine pulmonary arterial smooth muscle cells #MMPMID19084078 Hume JR ; McAllister CE ; Wilson SM Vascul Pharmacol 2009[Mar]; 50 (3-4 ): 89-97 PMID19084078 show ga Caffeine is a well described and characterized ryanodine receptor (RyR) activator. Previous evidence from independent research studies also indicate caffeine inhibits InsP3 receptor functionality, which is important to activation of capacitative Ca2+ entry (CCE) in some cell types. In addition, RyR activation elicits excitatory-coupled Ca2+ entry (ECCE) in skeletal muscle myotubes. Recent studies by our group show that canine pulmonary arterial smooth muscle cells (PASMCs) have functional InsP3 receptors as well as RyRs, and that CCE is dependent on InsP3 receptor activity. The potential for caffeine to activate ECCE as well as inhibit InsP3 receptor function and CCE was examined using fura-2 fluorescent imaging in canine PASMCs. The data show caffeine causes transient as well as sustained cytosolic Ca2+ increases, though this is not due to CCE or ECCE activity as evidenced by a lack of an increase in Mn2+ quench of fura-2. The experiments also show caffeine reversibly inhibits 5-HT elicited-InsP3 mediated Ca2+ responses with an IC50 of 6.87x10(-4) M and 10 mM caffeine fully inhibits CCE. These studies provide the first evidence that caffeine is an inhibitor of InsP3 generated Ca2+ signals and CCE in PASMCs. |Animals [MESH] |Caffeine/*pharmacology [MESH] |Calcium Channel Blockers/*pharmacology [MESH] |Calcium Signaling/drug effects [MESH] |Calcium/*metabolism [MESH] |Cell Line [MESH] |Dogs [MESH] |Female [MESH] |Humans [MESH] |In Vitro Techniques [MESH] |Inositol 1,4,5-Trisphosphate/*antagonists & inhibitors [MESH] |Male [MESH] |Myocytes, Smooth Muscle/*drug effects/metabolism [MESH] |Pulmonary Artery/*metabolism [MESH]Caffeine inhibits InsP3 responses and capacitative calcium entry in ca(epmc).pdf DeepDyve Pubget Overpricing