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10.1073/pnas.0812689106 http://scihub22266oqcxt.onion/10.1073/pnas.0812689106 C2635800!2635800 !19164548     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\19164548 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Proc+Natl+Acad+Sci+U+S+A 2009 ; 106 (5 ): 1560-5 Nephropedia Template TP {{tp|p=19164548 |t=2009. A critical role for the sphingosine analog AAL-R in dampening the cytokine response during influenza virus infection |pdf=|usr=}}{{19164548 }} gab.com Text A critical role for the sphingosine analog AAL-R in dampening the cytokine response during influenza virus infection JO: Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=19164548 #FOAvip Pulmonary tissue damage resulting from influenza virus infection is caused by both the cytolytic activity of the virus and the host immune response. Immune-mediated injury results from T cell-mediated destruction of virus-infected cells and by release of cytokines and chemokines that attract polymorphonuclear leukocytes (PML) and macrophages to the infected site. The cytokines/chemokines potentiate dendritic cell (DC) activation and T cell expansion, which further enhances local damage. Here we report that immune modulation by local administration to the respiratory tract of sphingosine analog AAL-R significantly dampens the release of cytokines and chemokines while maintaining protective neutralizing antibody and cytotoxic T cell responses. As a result there was a marked reduction of infiltrating PML and macrophages into the lung and resultant pulmonary tissue injury. DC maturation was suppressed, which limited proliferation of specific antiviral T cells in the lung and draining lymph nodes. Further, AAL-R was effective in controlling CD8(+) T cell accumulation in the lungs even when given 4 days after initiation of influenza virus infection. These data indicate that sphingosine analogs display useful potential for controlling the immunopathology caused by influenza virus. Twit Text FOAVip A critical role for the sphingosine analog AAL-R in dampening the cytokine response during influenza virus infection ????Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=19164548 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=19164548 #FOAvip English Wikipedia <ref>{{Cite pmid|19164548 }}</ref> A critical role for the sphingosine analog AAL-R in dampening the cytokine response during influenza virus infection #MMPMID19164548 Marsolais D ; Hahm B ; Walsh KB ; Edelmann KH ; McGavern D ; Hatta Y ; Kawaoka Y ; Rosen H ; Oldstone MB Proc Natl Acad Sci U S A 2009[Feb]; 106 (5 ): 1560-5 PMID19164548 show ga Pulmonary tissue damage resulting from influenza virus infection is caused by both the cytolytic activity of the virus and the host immune response. Immune-mediated injury results from T cell-mediated destruction of virus-infected cells and by release of cytokines and chemokines that attract polymorphonuclear leukocytes (PML) and macrophages to the infected site. The cytokines/chemokines potentiate dendritic cell (DC) activation and T cell expansion, which further enhances local damage. Here we report that immune modulation by local administration to the respiratory tract of sphingosine analog AAL-R significantly dampens the release of cytokines and chemokines while maintaining protective neutralizing antibody and cytotoxic T cell responses. As a result there was a marked reduction of infiltrating PML and macrophages into the lung and resultant pulmonary tissue injury. DC maturation was suppressed, which limited proliferation of specific antiviral T cells in the lung and draining lymph nodes. Further, AAL-R was effective in controlling CD8(+) T cell accumulation in the lungs even when given 4 days after initiation of influenza virus infection. These data indicate that sphingosine analogs display useful potential for controlling the immunopathology caused by influenza virus. |Amino Acid Sequence [MESH] |Animals [MESH] |Antibodies, Viral/biosynthesis/immunology [MESH] |Antigen-Presenting Cells/immunology [MESH] |Base Sequence [MESH] |Cytokines/*biosynthesis [MESH] |DNA, Viral [MESH] |Disease Models, Animal [MESH] |Humans [MESH] |Influenza, Human/immunology/metabolism/*physiopathology [MESH] |Lung/immunology [MESH] |Mice [MESH] |Molecular Sequence Data [MESH] |Neutralization Tests [MESH] |Sphingosine/*pharmacology [MESH]A critical role for the sphingosine analog AAL-R in dampening the cyto(epmc).pdf DeepDyve Pubget Overpricing