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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Virology
2008 ; 381
(1
): 22-8
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Analysis of cytokine secretion from human plasmacytoid dendritic cells infected
with H5N1 or low-pathogenicity influenza viruses
#MMPMID18801551
Sandbulte MR
; Boon AC
; Webby RJ
; Riberdy JM
Virology
2008[Nov]; 381
(1
): 22-8
PMID18801551
show ga
Mechanisms underlying the virulence of H5N1 influenza viruses in humans are
poorly understood, though evidence of hyperinflammation and systemic viral
replication has been reported. Plasmacytoid dendritic cells (PDCs), a major
source of type I interferon, potentially affect host defense against influenza
viruses. To analyze how influenza virus infection alters PDC function, we
measured cytokine secretion from primary human PDCs infected with high- or
low-pathogenicity influenza viruses. IFN-alpha responses induced by H5N1 viruses
were several-fold higher than those induced by low-pathogenicity strains;
differences in the secretion of the proinflammatory cytokines TNF-alpha and IP-10
were less pronounced, in contrast with findings from human macrophage studies.
Reassortant viruses bearing H5N1-derived NS genes did not elicit enhanced
IFN-alpha secretion by PDCs; thus, other H5N1 gene(s) are responsible for the
heightened response. Their central role in the induction of an effective
antiviral immune response and the finding that they respond differently to
influenza viruses of different pathogenicities suggest that PDCs may play a role
in the hypercytokinemia associated with H5N1 infection in humans.
|Cytokines/*metabolism
[MESH]
|Dendritic Cells/*metabolism/*virology
[MESH]
|Humans
[MESH]
|Influenza A Virus, H5N1 Subtype/genetics/*immunology/pathogenicity
[MESH]
free
free
free
